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Discovering novel viruses in communities encroaching tropical hotspots via a metagenomics approach

Grant number: 13/22136-1
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): July 01, 2014
Effective date (End): February 28, 2018
Field of knowledge:Biological Sciences - Microbiology
Principal Investigator:Paolo Marinho de Andrade Zanotto
Grantee:Nicholas Di Paola
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Metagenomic approaches have demonstrated a huge array of unknown viruses present in the environment and in human populations. Fragmentation and encroachment of tropical rainforests in Brazil have exponentially increased chances for human exposure to diverse, exotic and novel zoonotic viruses. Several South-Atlantic tropical rainforests border small human populations that have access to densely populated metropolises and international seaports. Given the large potential for spill-over, we will collect serum samples from communal zones that geographically have the greatest contact with these tropical hotspots. In this project, we aim to identify novel viruses using (1) a deep-sequencing approach and (2) an in silico approach via Hidden Markov Model profiling. We hope to further characterize putative novel viruses by attempting to culture them in cells for future research and to determine the prevalence of human infection through serology. (AU)

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DI PAOLA, NICHOLAS; CUNHA, MARIELTON DOS PASSOS; DURIGON, GIULIANA STRAVINSKAS; BEREZIN, EITAN NAAMAN; DURIGON, EDISON; LEAL DE OLIVEIRA, DANIELLE BRUNA; DE ANDRADE ZANOTTO, PAOLO MARINHO. Complete Genome Sequences of Five Human Respiratory Syncytial Virus Isolates Collected in Brazil. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 6, n. 7, . (14/17766-9, 16/08204-2, 13/22136-1)
FALL, GAMOU; DI PAOLA, NICHOLAS; FAYE, MARTIN; DIA, MOUSSA; DE MELO FREIRE, CAIO CESAR; LOUCOUBAR, CHEIKH; DE ANDRADE ZANOTTO, PAOLO MARINHO; FAYE, OUSMANE; SALL, AMADOU ALPHA. Biological and phylogenetic characteristics of West African lineages of West Nile. PLoS Neglected Tropical Diseases, v. 11, n. 11, . (14/17766-9, 13/22136-1)
DI PAOLA, NICHOLAS; CUNHA, MARIELTON DOS PASSOS; DURIGON, GIULIANA STRAVINSKAS; BEREZIN, EITAN NAAMAN; DURIGON, EDISON; LEAL DE OLIVEIRA, DANIELLE BRUNA; DE ANDRADE ZANOTTO, PAOLO MARINHO. Complete Genome Sequences of Two Human Parainfluenza Virus Type 3 Isolates Collected in Brazil. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 5, n. 49, . (14/17766-9, 16/08204-2, 13/22136-1)
DI PAOLA, NICHOLAS; MESQUITA, FLAVIO S.; LEAL DE OLIVEIRA, DANIELLE BRUNA; VILLABONA-ARENAS, CHRISTIAN JULIAN; POUR, SHAHAB ZAKI; DE SOUSA-CAPRA, CARLA; LOPES, GABRIELA PESSANHA; FERRAZ SANTANA, RUBIA ANITA; REBELLO PINHO, JOAO RENATO; BALARINI, KARIME; et al. An Outbreak of Human Parvovirus B19 Hidden by Dengue Fever. Clinical Infectious Diseases, v. 68, n. 5, p. 810-817, . (14/17766-9, 15/25643-7, 13/22136-1)
DI PAOLA, NICHOLAS; DE MELO FREIRE, CAIO CESAR; DE ANDRADE ZANOTTO, PAOLO MARINHO. Does adaptation to vertebrate codon usage relate to flavivirus emergence potential?. PLoS One, v. 13, n. 1, . (13/22136-1)
DI PAOLA, NICHOLAS; CUNHA, MARIELTON DOS PASSOS; DURIGON, GIULIANA STRAVINSKAS; BEREZIN, EITAN NAAMAN; DURIGON, EDISON; LEAL OLIVEIRA, DANIELLE BRUNA; DE ANDRADE ZANOTTO, PAOLO MARINHO. Complete Genome Sequence of a Human Metapneumovirus Isolate Collected in Brazil. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 6, n. 6, . (14/17766-9, 16/08204-2, 13/22136-1)
BARBOSA, CARLA M.; DI PAOLA, NICHOLAS; CUNHA, MARIELTON P.; RODRIGUES-JESUS, MONICA J.; ARAUJO, DANIELLE B.; SILVEIRA, VANESSA B.; LEAL, FABYANO B.; MESQUITA, FLAVIO S.; BOTOSSO, VIVIANE F.; ZANOTTO, PAOLO M. A.; et al. Yellow Fever Virus RNA in Urine and Semen of Convalescent Patient, Brazil. Emerging Infectious Diseases, v. 24, n. 1, p. 176-178, . (14/17766-9, 14/21141-4, 16/08727-5, 13/22136-1, 16/08204-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PAOLA, Nicholas Di. Discovering and characterizing emerging and re-emerging viruses in communities encroaching tropical hotspots.. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.