Bladder transitional cell carcinoma: a study of pos-transcriptional modifications and RNA binding proteins

• Grant number: 13/23279-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: August 01, 2014
• End date: January 31, 2019
• Field of knowledge: Biological Sciences - Genetics - Human and Medical Genetics
• Principal Investigator: Daisy Maria Favero Salvadori
• Grantee: André Luiz Ventura Sávio
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated scholarship(s): 16/05556-5 - Functional analysis of 14 RNA binding proteins (RBPs) in two bladder urothelial carcinoma cell lines, BE.EP.DR

Abstract

Cancer is characterized as a serious public health problem. Particularly, bladder cancer has a high cost to health system, especially given the need for routine clinical monitoring (urine cytology and cystoscopy) and high recurrence rate. Due to the complexity of biological systems, little is known about the molecular mechanisms responsible for urothelial carcinomas. The literature shows that in cancer there is involvement of a complex network of pathways affecting a large number of cellular processes such as apoptosis, proliferation, invasion, growth, etc. In this context, we highlight RNA-binding proteins (RPBs), post-transcriptional regulators of gene expression which are involved in splicing, polyadenylation, stability, degradation and transport of RNAs and translation. To investigate the impact of RPBs and RNA processing events in the development of different degrees of bladder tumor, this study proposes to evaluate biopsies from 60 patients with bladder cancer (30 low-grade tumors and 30 high-grade tumors). Ten bladder biopsies from patients with benign prostatic hyperplasia will be used as control. We expect results might illuminate new mechanisms of tumorigenesis and provide information relevant to the identification of biomarkers for early prognosis and treatment of urothelial carcinomas.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VENTURA SAVIO, A. L.; MOREIRA LEITE, K. R.; BURNS, S.; DA SILVA, G. N.; FAVARETTO GALANTE, P. A.; FERRAZ PENALVA, L. O.; FAVERO SALVADORI, D. M.. Musashi-1 RNA binding protein a new biomarker candidate and therapeutic target in urothelial carcinoma.. Environmental and Molecular Mutagenesis, v. 59, p. 1-pg., 2018-09-01. (14/05386-7, 16/05556-5, 13/23279-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SÁVIO, André Luiz Ventura. Urothelial Carcinoma: a study of post-transcriptional and RNA binding protein. 2019. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Botucatu Botucatu.