Three-dimensional assessment of upper airways in patients with cleft lip and palate and maxillomandibular discrepancy

• Grant number: 14/12574-4
• Support Opportunities: Scholarships abroad - Research Internship - Master's degree
• Start date: November 01, 2014
• End date: January 31, 2015
• Field of knowledge: Health Sciences - Dentistry - Oral and Maxillofacial Surgery
• Principal Investigator: Ivy Kiemle Trindade Suedam
• Grantee: Thiago Freire Lima
• Supervisor: Luiz André Freire Pimenta
• Host Institution: Hospital de Reabilitação de Anomalias Craniofaciais (HRAC). Universidade de São Paulo (USP). Bauru , SP, Brazil
• Institution abroad: University of North Carolina at Chapel Hill (UNC), United States
• Associated to the scholarship: 13/24524-9 - THREE-DIMENSIONAL ANALYSIS OF UPPER AIRWAYS IN PATIENTS WITH CLEFT LIP AND PALATE AND MAXILLOMANDIBULAR DISCREPANCY, BP.MS

Abstract

Cleft lip and palate (CLP) is the most prevalent congenital malformation in humans. Primary plastic surgeries, which main objective is to repair the anatomy and the function of the lip and palate, paradoxically, impair maxillary growth and, consequently, impact negatively on the nasal morphophysiology, leading to deformities such as septal deviation and turbinate hypertrophy. These changes reduce the internal nasal dimensions and increase the resistance to respiratory airflow. Assuming that, as in the nasal cavity, pharyngeal volume in CLP individuals is probably reduced, the aim of this study is to evaluate three-dimensionally the pharyngeal airway space of this population by means of cone beam computed tomography. For this, two groups will be evaluated: 1) Control group: 30 CT scans of individuals without CLP and with class III malocclusion, and 2) Cleft group: 30 CT scans of individuals with unilateral CLP and with class III malocclusion. The scans will be obtained in the HRAC database and in a maxillofacial surgery clinic in the city of Bauru. It will be assessed retrospectively using Dolphin Imaging 11.0 software, which is able to reformat the volume (mm3) and determine the minimal cross-sectional areas of the pharynx (mm2). Therefore, it is expected to find reduced values of pharyngeal areas and volumes for CLP patients, as compared to individuals without clefts. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GARCIA-USO, MICHELE; LIMA, THIAGO F.; TRINDADE, INGE ELLY K.; PIMENTA, LUIZ ANDRE F.; TRINDADE-SUEDAM, IVY KIEMLE. Three-dimensional tomographic assessment of the upper airway using 2 different imaging software programs: A comparison study. AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS, v. 159, n. 2, p. 217-223, FEB 2021. (13/24524-9, 14/12574-4)