Bacterial symbionts isolated from fungus-growing ants collected in remaining hotspots of biodiversity in São Paulo State as sources of antiparasitic compounds

• Grant number: 14/14095-6
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: August 01, 2014
• End date: December 31, 2018
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Agreement: National Institutes of Health (NIH)
• Principal Investigator: Mônica Tallarico Pupo
• Grantee: Humberto Enrique Ortega Dominguez
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 13/50954-0 - Novel therapeutic agents from the bacterial symbionts of Brazilian invertebrates, AP.BTA.TEM
• Associated scholarship(s): 16/20154-0 - Exploring antimicrobial, anticancer and antiparasitic compounds from bacterial symbionts isolated from Acromyrmex ants, collected in São Paulo State, Brazil, BE.EP.DD

Abstract

This Doctorate (DD) fellowship will give graduate student the opportunity to develop his/her research in different topics of the entire ICBG project, from insect collection to natural product identification. Insect collections will be in the Vassununga State Park, SP, which still houses remaining areas of Atlantic Forest and Cerrado in São Paulo State. Bacterial strains will be isolated and preserved, and further cultured for extracts preparation. Extracts will be evaluated in the ICBG primary assays and antiparasitic hits (Chagas' disease and leishmaniasis) will be selected for further chemical studies aiming the identification of new natural products useful for therapeutical development. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CHEVRETTE, MARC G.; CARLSON, CAITLIN M.; ORTEGA, HUMBERTO E.; THOMAS, CHRIS; ANANIEV, GENE E.; BARNS, KENNETH J.; BOOK, ADAM J.; CAGNAZZO, JULIAN; CARLOS, CAMILA; FLANIGAN, WILL; et al. The antimicrobial potential of Streptomyces from insect microbiomes. NATURE COMMUNICATIONS, v. 10, JAN 31 2019. (14/14095-6, 15/01001-6, 13/50954-0)

ORTEGA, HUMBERTO E.; BATISTA, JR., JOAO M.; MELO, WEILAN G. P.; DE PAULA, GABRIELA T.; PUPO, MONICA T.. Structure and Absolute Configuration of Secondary Metabolites from Two Strains of Streptomyces chartreusis Associated with Attine Ants. Journal of the Brazilian Chemical Society, v. 30, n. 12, SI, p. 2672-2680, DEC 2019. (15/07089-2, 13/50954-0, 14/25222-9, 14/14095-6, 17/05920-1, 15/01001-6)

ORTEGA, HUMBERTO E.; FERREIRA, LEONARDO L. G.; MELO, WEILAN G. P.; OLIVEIRA, ANA LIGIA L.; RAMOS ALVARENGA, RENE F.; LOPES, NORBERTO P.; BUGNI, TIM S.; ANDRICOPULO, ADRIANO D.; PUPO, MONICA T.. Antifungal compounds from Streptomyces associated with attine ants also inhibit Leishmania donovani. PLoS Neglected Tropical Diseases, v. 13, n. 8, AUG 2019. (13/07600-3, 13/50954-0, 15/01001-6, 14/14095-6, 16/15872-1, 16/20154-0)

ORTEGA, HUMBERTO E.; LOURENZON, VITOR B.; CHEVRETTE, MARC G.; FERREIRA, LEONARDO L. G.; ALVARENGA, RENE F. RAMOS; MELO, WEILAN G. P.; VENANCIO, TIAGO; CURRIE, CAMERON R.; ANDRICOPULO, ADRIANO D.; BUGNI, TIM S.; et al. Antileishmanial macrolides from ant-associated Streptomyces sp. ISID311. Bioorganic & Medicinal Chemistry, v. 32, FEB 15 2021. (13/25658-9, 16/17614-0, 14/14095-6, 13/50954-0, 19/16559-3, 13/07600-3, 16/20154-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

DOMINGUEZ, Humberto Enrique Ortega. Antifungal and Antileishmanial Natural Products from Actinobacteria Associated to Brazilian Fungus-Growing Ants. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.