Application of multivariate statistical techniques for the mapping of the cases of intoxication attended in poison control center in São Paulo City

• Grant number: 14/05877-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: October 01, 2014
• End date: February 28, 2018
• Field of knowledge: Health Sciences - Pharmacy - Toxicological Analysis
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Mauricio Yonamine
• Grantee: Sarah Carobini Werner de Souza Eller Franco de Oliveira
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Over the years, clinical toxicologists were shifting their primary focus of treatment of acutely intoxicated patients for hazard identification and risk assessment of toxic environmental and occupational exposures in humans. According to Pan American Health Organization, any approach to be successful, health experts, policymakers, program managers and others need reliable information. They need to understand the scope of the problem and the target population, which can be obtained through mapping and epidemiological characterization of cases of poisoning. The multivariate analysis techniques are statistical methods appropriate for the study of relationships between variables that contain intercorrelations. Among the various techniques stand out hierarchical cluster analysis (HCA) and principal components analysis (PCA). The multivariate analysis techniques have been widely applied in various fields of engineering and economics, however, in clinical toxicology, this approach is still relatively recent. Therefore, the objective of this project is the application of multivariate statistical techniques for the mapping of the cases acute of intoxication subject to toxicological analysis, attended in Poison Control Center in São Paulo city (CCI-SP). Questionnaires will be applied to obtain information such as age, sex, route of exposure, presented symptoms and developments in the case. Concomitantly, blood and urine samples will be collected (n=1000) for identification and quantification of plasmatic substance involved, by chromatographic techniques. The choice of the analytes to be studied (analgesics, anxiolytics, antidepressants, anticonvulsants, drug abuse and pesticides) is based on the higher incidence of poisoning cases registered by the Sistema de Informação de Agravos de Notificação (SINAN). Thereby, we shall show that the techniques of multivariate analyzes are useful tools to identify and characterize risk groups and thus provide scientific basis, through the creation of a database, to guide emergency interventions and promote preventive actions. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ELLER, SARAH; ZUCOLOTO, ALEXANDRE DIAS; RODRIGUES DE OLIVEIRA, CAROLINA DIZIOLI; MIELLO HERNANDEZ, EDNA MARIA; GIMENEZ FRUCHTENGARTEN, LIGIA VERAS; MEIRA DE OLIVEIRA, FLAVIA NERI; DE OLIVEIRA, TIAGO FRANCO; YONAMINE, MAURICIO. Multivariate analysis applied in dataset of Poison Control Center of SAo Paulo, Brazil. SCIENTIFIC REPORTS, v. 10, n. 1, JUN 11 2020. (14/05877-0)

ZUCOLOTO, ALEXANDRE D.; ELLER, SARAH; DE OLIVEIRA, TIAGO F.; WAGNER, GABRIELA A.; FRUCHTENGARTEN, LIGIA V. G.; DE OLIVEIRA, CAROLINA D. R.; YONAMINE, MAURICIO. Relationship between cocaine and cocaethylene blood concentration with the severity of clinical manifestations. AMERICAN JOURNAL OF EMERGENCY MEDICINE, v. 50, p. 404-408, DEC 2021. (14/05877-0)

FRANCO DE OLIVEIRA, SARAH C. W. S. E.; ZUCOLOTO, ALEXANDRE D.; DE OLIVEIRA, CAROLINA D. R.; HERNANDEZ, EDNA M. M.; FRUCHTENGARTEN, LIGIA V. G.; DE OLIVEIRA, TIAGO F.; YONAMINE, MAURICIO. Development of a simple HPLC-DAD multi-analyte procedure and its application in cases evaluated by the Poison Control Center of Sao Paulo, Brazil. BIOMEDICAL CHROMATOGRAPHY, v. 32, n. 12, DEC 2018. (14/05877-0)

FRANCO DE OLIVEIRA, SARAH C. W. S. E.; ZUCOLOTO, ALEXANDRE D.; DE OLIVEIRA, CAROLINA D. R.; HERNANDEZ, EDNA M. M.; FRUCHTENGARTEN, LIGIA V. G.; DE OLIVEIRA, TIAGO F.; YONAMINE, MAURICIO. A fast and simple approach for the quantification of 40 illicit drugs, medicines, and pesticides in blood and urine samples by UHPLC-MS/MS. Journal of Mass Spectrometry, v. 54, n. 7, p. 600-611, JUL 2019. (14/05877-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

OLIVEIRA, Sarah Carobini Werner de Souza Eller Franco de. Application of multivariate analysis for the mapping of acute intoxication cases attended in Poison Control Center of the São Paulo city. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.