Cytokine profile in newly professionals exposed to waste anesthetic gases

• Grant number: 14/08661-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2014
• End date: October 31, 2016
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Mariana Gobbo Braz
• Grantee: Ludimila Oliveira Resende
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Reports have shown that anesthetics may have influence on immune system of patients undergoing surgery. On the other hand, whether there is alteration of immune system in professionals occupationally exposed to anesthetic gases remains unknown. The goal of this study is to assess the immune response in professionals who are occupationally exposed to waste anesthetic gases. Forty physicians who work at "Hospital das Clínicas, Faculdade de Medicina de Botucatu - UNESP" will be allocated in two groups, as follows: the exposed group (n=20) - medical residents who work in operating rooms and who are exposed to isoflurane, sevoflurane and nitrous oxide, and the control group (n=20) - medical residents not exposed to waste anesthetic gases. Blood samples will be drawn for each group and the cytokine profile will be detected by flow cytometry, using Cytometric Bead Array. Thus, this study intends to contribute for better understanding the possible role of waste anesthetic gases on immune system of newly exposed professionals.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BRAZ, MARIANA G.; CARVALHO, LORENA I. M.; CHEN, CHUNG-YEN O.; BLUMBERG, JEFFREY B.; SOUZA, KATINA M.; ARRUDA, NAYARA M.; FILHO, DANIEL A. A.; RESENDE, LUDIMILA O.; FARIA, RENATA T. B. G.; CANARIO, CLARA D'A; et al. High concentrations of waste anesthetic gases induce genetic damage and inflammation in physicians exposed for three years: A cross-sectional study. INDOOR AIR, v. 30, n. 3, p. 512-520, MAY 2020. (13/12120-0, 13/21130-0, 15/06420-7, 13/18075-7, 14/08661-9)