Influence of age, diet and tissue in response of creatine supplementation

• Grant number: 14/06911-8
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: August 01, 2014
• End date: March 31, 2017
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Bruno Gualano
• Grantee: Marina Yazigi Solis
• Host Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

It has been postulated that the magnitude of the effects of creatine (Cr) supplementation on Cr tissue content may be affected by age, diet and target-tissue. However, there is a paucity of data confirming this speculation. Therefore, the aim of this study will be to determine whether the Cr responses vary as a function of age, diet, and tissue in humans. A single-blind placebo-controlled trial will be conducted. It will be selected 20 children, 20 elderly and 40 adult (20 omnivorous and 20 vegetarians) healthy and physically active subjects. The subjects will be supplemented with placebo for 7 days and, subsequently to a 5-d washout period, Cr for 7 days (0,3g/Kg/d body weight). Prior to and after the intervention, muscle and brain Cr concentrations will be measured by hydrogen proton magnetic resonance spectroscopy (1H-MRS). To determine whether there is an interference of age on Cr supplementation response, children, adults and elderly subjects will be compared. To assess whether diet plays a role in the Cr response, omnivorous and vegetarians will be compared. Finally, to test the possible differential response among tissues to Cr supplementation, brain and skeletal muscle responses will be compared in children, adults and elderly subjects. The determination of factors that affect the Cr supplementation response will lead to a substantial qualitative advance in the area by improving the knowledge on the outcomes from previous clinical studies, the development of new trials with different populations, and the application of Cr supplementation in clinical setting. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FELAU, SHEYLLA M.; SALES, LUCAS P.; SOLIS, MARINA Y.; HAYASHI, ANA PAULA; ROSCHEL, HAMILTON; SA-PINTO, ANA LUCIA; OLIVEIRA DE ANDRADE, DANIELI CASTRO; KATAYAMA, KEYLA Y.; IRIGOYEN, MARIA CLAUDIA; CONSOLIM-COLOMBO, FERNANDA; et al. Omega-3 Fatty Acid Supplementation Improves Endothelial Function in Primary Antiphospholipid Syndrome: A Small-Scale Randomized Double-Blind Placebo-Controlled Trial. FRONTIERS IN IMMUNOLOGY, v. 9, MAR 2 2018. (17/02546-1, 14/06911-8)