Effect of dietary oleic acid on fatty acid composition and inflammatory response profile in different tissues of pigs

• Grant number: 18/26797-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): August 01, 2019
• Effective date (End): January 31, 2021
• Field of knowledge: Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
• Principal Investigator: Aline Silva Mello Cesar
• Grantee: Julia Pereira Martins da Silva
• Host Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil
• Associated research grant: 17/25180-2 - Effect of dietary oleic acid on fatty acid composition and inflammatory response profile in different tissues of pigs, AP.JP
• Associated scholarship(s): 20/00238-0 - Sensorial analysis of broiler breast fillets with muscle myopathy, BE.EP.IC

Abstract

Lipids are a class of molecules present in all cell types. They contribute to cellular structure, energy storage and several biological functions from transcriptional regulation to physiological processes. These molecules are also responsible for the nutritional value of the meat, which is directly influenced by the animal's diet. Meat has high nutritional value and is an important source of unsaturated fatty acids (FA) such as oleic acid (OA, C18:1 cis 9) and linoleic acid (LA, C18:2 cis9, 12), which have beneficial effects on human health. Previous studies have reported an important contribution of OA intake to general human health, which could lead to a decrease in cholesterol levels, atherosclerosis risk, and diabetes occurrence. Further, OA has protective effects against viral infection and cancer development. Meat has a high unsaturated fatty acid profile and considered an important source of OA in human nutrition and health. Our hypothesis is the OA included in finishing the diet of pigs can change the transcriptomic and inflammatory response profile of different tissues such as skeletal muscle, liver, and brain affecting several biological processes and consequently the phenotypic characteristics of the animals. Thus, the objectives of this study are: (1) identify changes in the pig skeletal muscle, liver, and brain transcriptome and inflammatory response profile induced by a diet enriched with oleic acid; (2) characterize the biological processes related to metabolic diseases, inflammatory reactions, and immune responses; (3) evaluate the organoleptic, physical and sensory characteristics of the meat; and (4) the feed efficiency of animals.

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

JULIA PEREIRA MARTINS DA SILVA; VIVIAN VEZZONI ALMEIDA; ALLAN PAUL SCHINCKEL; ARIANA NASCIMENTO MEIRA; GABRIEL COSTA MONTEIRO MOREIRA; LAURA WOIGT PIAN; DÉBORA DE CAMPOS; JULIA DEZEN GOMES; JANAÍNA LUSTOSA GONÇALES; MARIANA DAMIAMES BACCARIN DARGELIO; et al. Check-All-That-Apply method for sensory characterization of pork from immunocastrated male pigs fed different oil sources. Scientia Agricola, v. 80, 2022-09-12. (18/15653-3, 18/26797-6, 20/00743-7)

FANALLI, SIMARA LARISSA; SILVA, BRUNA PEREIRA MARTINS; GOMES, JULIA DEZEN; DURVAL, MARIAH CASTRO; DE ALMEIDA, VIVIAN VEZZONI; MOREIRA, GABRIEL COSTA MONTEIRO; SILVA-VIGNATO, BARBARA; AFONSO, JULIANA; FREITAS, FELIPE ANDRE OLIVEIRA; REECY, JAMES MARK; et al. RNA-seq transcriptome profiling of pigs' liver in response to diet with different sources of fatty acids. FRONTIERS IN GENETICS, v. 14, p. 14-pg., 2023-01-25. (21/06553-8, 20/10042-6, 18/15653-3, 18/26816-0, 14/02493-7, 17/25180-2, 18/26797-6)

DA SILVA, BRUNA PEREIRA MARTINS; FANALLI, SIMARA LARISSA; GOMES, JULIA DEZEN; DE ALMEIDA, VIVIAN VEZZONI; FUKUMASU, HEIDGE; FREITAS, FELIPE ANDRE OLIVEIRA; MOREIRA, GABRIEL COSTA MONTEIRO; SILVA-VIGNATO, BARBARA; REECY, JAMES MARK; KOLTES, JAMES EUGENE; et al. Brain fatty acid and transcriptome profiles of pig fed diets with different levels of soybean oil. BMC Genomics, v. 24, n. 1, p. 13-pg., 2023-02-28. (18/26797-6, 17/25180-2, 18/15653-3, 18/26816-0, 21/01694-2, 20/10042-6)

FANALLI, SIMARA LARISSA; DA SILVA, BRUNA PEREIRA MARTINS; GOMES, JULIA DEZEN; DE ALMEIDA, VIVIAN VEZZONI; MOREIRA, GABRIEL COSTA MONTEIRO; SILVA-VIGNATO, BARBARA; AFONSO, JULIANA; FREITAS, FELIPE ANDRE OLIVEIRA; REECY, JAMES MARK; KOLTES, JAMES EUGENE; et al. Transcriptome profile of skeletal muscle using different sources of dietary fatty acids in male pigs. FUNCTIONAL & INTEGRATIVE GENOMICS, v. 23, n. 1, p. 19-pg., 2023-03-01. (21/06553-8, 20/10042-6, 18/15653-3, 18/26816-0, 14/02493-7, 17/25180-2, 18/26797-6)

MARTINS DA SILVA, JULIA PEREIRA; ALMEIDA, VIVIAN VEZZONI; SCHINCKEL, ALLAN PAUL; MEIRA, ARIANA NASCIMENTO; MONTEIRO MOREIRA, GABRIEL COSTA; PIAN, LAURA WOIGT; DE CAMPOS, DEBORA; GOMES, JULIA DEZEN; GONCALES, JANAINA LUSTOSA; BACCARIN DARGELIO, MARIANA DAMIAMES; et al. Check-All-That-Apply method for sensory characterization of pork from immunocastrated male pigs fed different oil sources. CIENTIA AGRICOL, v. 80, p. 8-pg., 2023-01-01. (18/26797-6, 20/00743-7)

FANALLI, SIMARA LARISSA; MARTINS DA SILVA, BRUNA PEREIRA; GOMES, JULIA DEZEN; DE ALMEIDA, VIVIAN VEZZONI; OLIVEIRA FREITAS, FELIPE ANDRE; MONTEIRO MOREIRA, GABRIEL COSTA; SILVA-VIGNATO, BARBARA; AFONSO, JULIANA; REECY, JAMES; KOLTES, JAMES; et al. Differential Gene Expression Associated with Soybean Oil Level in the Diet of Pigs. ANIMALS, v. 12, n. 13, p. 21-pg., 2022-07-01. (17/25180-2, 18/26797-6, 14/02493-7, 20/14148-3, 20/10042-6, 18/26816-0, 18/15653-3)

FANALLI, SIMARA LARISSA; MARTINS DA SILVA, BRUNA PEREIRA; GOMES, JULIA DEZEN; CICONELLO, FERNANDA NERY; DE ALMEIDA, VIVIAN VEZZONI; OLIVEIRA FREITAS, FELIPE ANDRE; MONTEIRO MOREIRA, GABRIEL COSTA; SILVA-VIGNATO, BARBARA; AFONSO, JULIANA; REECY, JAMES; et al. Effect of dietary soybean oil inclusion on liver-related transcription factors in a pig model for metabolic diseases. SCIENTIFIC REPORTS, v. 12, n. 1, p. 10-pg., 2022-06-20. (17/25180-2, 18/26797-6, 14/02493-7, 18/15653-3, 18/26816-0, 20/10042-6)