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Involvement of microRNAs on the accelerated ageing process caused by obesity

Grant number: 14/20380-5
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): January 01, 2015
Effective date (End): December 31, 2015
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Silvana Auxiliadora Bordin da Silva
Grantee:Daniella Esteves Duque Guimarães
Supervisor abroad: Susan Ozanne
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Local de pesquisa : University of Cambridge, England  
Associated to the scholarship:14/09118-7 - The involvement of microRNAs in the accelerated ageing process caused by obesity and the potential intervention by caloric restriction, fatty acid supplementation and exercise, BP.PD

Abstract

Several studies have demonstrated the deleterious effects of the maternal obesity on the metabolism of the offspring including accelerating the onset of conditions traditionally associated with ageing, as type 2 diabetes. On the last years, Ozanne´s group has found the participation of an accelerated celular senescence process on the offspring of obese mothers. More recently, skeletal muscle was also identified as a tissue that has been involved to the process of early ageing as consequence of the maternal obesity. The understanding of the ageing process on the effects of maternal obesity on the offspring would add a robust contribution to the field, once they become diabetics later in life. Moreover the involvement of microRNAs (miRNAs) on this context represents another relevant mechanism that could bring a deeper contribution to the understanding of the consequences of maternal obesity on the offspring. Ozanne´s group has also showed that a distinct modification in the profile of miRNAs could be associated to an exposure to an obesogenic environment in utero. Considering that miRNAs are potentially biomarkers for detection of diseases, the main goal of the current project is identify dysregulated miRNAs and their targets on the offspring of obese mothers that could be closely related to the development of diabetes. For the purpose of this project, RNA-seq, proteomics-SILAC and in silico analysis will be used to achieve the goal. Thus, this project would build up a valuable contribution of making the early identification of individuals at high risk of developing diabetes possible. (AU)

Articles published in other media outlets: (3 total)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MUSIAL, BARBARA; FERNANDEZ-TWINN, DENISE S.; DUQUE-GUIMARAES, DANIELLA; CARR, SARAH K.; FOWDEN, ABIGAIL L.; OZANNE, SUSAN E.; SFERRUZZI-PERRI, AMANDA N. Exercise alters the molecular pathways of insulin signaling and lipid handling in maternal tissues of obese pregnant mice. PHYSIOLOGICAL REPORTS, v. 7, n. 16 AUG 2019. Web of Science Citations: 0.
DUQUE-GUIMARES, DANIELLA; OZANNE, SUSAN. Early nutrition and ageing: can we intervene?. BIOGERONTOLOGY, v. 18, n. 6, SI, p. 893-900, DEC 2017. Web of Science Citations: 3.
FARIA, JULIANA DE ALMEIDA; DUQUE-GUIMARAES, DANIELLA; CARPENTER, ASHA A. M.; LOCHE, ELENA; OZANNE, SUSAN E. A post-weaning obesogenic diet exacerbates the detrimental effects of maternal obesity on offspring insulin signaling in adipose tissue. SCIENTIFIC REPORTS, v. 7, MAR 24 2017. Web of Science Citations: 7.
FERNANDEZ-TWINN, DENISE S.; GASCOIN, GERALDINE; MUSIAL, BARBARA; CARR, SARAH; DUQUE-GUIMARAES, DANIELLA; BLACKMORE, HEATHER L.; ALFARADHI, MARIA Z.; LOCHE, ELENA; SFERRUZZI-PERRI, AMANDA N.; FOWDEN, ABIGAIL L.; OZANNE, SUSAN E. Exercise rescues obese mothers' insulin sensitivity, placental hypoxia and male offspring insulin sensitivity. SCIENTIFIC REPORTS, v. 7, MAR 14 2017. Web of Science Citations: 19.

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