Immature stem cells of human dental pulp: a new therapeutic strategy for the bone marrow aplasia treatment in animal models

• Grant number: 14/02768-6
• Support Opportunities: Scholarships in Brazil - Master
• Start date: October 01, 2014
• End date: April 30, 2016
• Field of knowledge: Biological Sciences - Morphology - Cytology and Cell Biology
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Irina Kerkis
• Grantee: Vivian Fonseca Gonzaga
• Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated research grant: 10/51051-6 - Adult stem cells versus induced pluripotent stem cells, AP.TEM

Abstract

Aplastic anemia is a disease characterized by a partial or complete bone marrow failure, through a pluripotent Stem Cell Hematopoietic (HSC) assault, leading to decline and even absence of bone marrow. The treatment is typically given by HSC transplantation and administration of immunosuppressive drugs, but these processes are restricted since the necessity of cell compatibility to the effects of this drug. Thus, the search for new hematologic malignancies therapies has been continuously growing. And in the current knowledge of autocrine and paracrine promising ability of Mesenchymal Stem Cells (MSC) in hematological diseases, these cells have the potential to treat aplastic marrow disease without manifesting effects experienced with the use of CTH (graft-host) and immunosuppressive drugs. Also, has not demonstrated the use of dental pulp MSC heterologous and cryopreserved for the treatment of bone marrow aplasia. Thus, the project proposes the use of MSC derived from human dental pulp to treat aplastic marrow in aplasic induced mice. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GONZAGA, VIVIAN FONSECA; WENCESLAU, CRISTIANE VALVERDE; VIEIRA, DANIEL PEREZ; POLICIQUIO, BRUNA DE OLIVEIRA; KHALIL, CHARBEL; ARALDI, RODRIGO PINHEIRO; KERKIS, IRINA. Therapeutic Potential of Human Immature Dental Pulp Stem Cells Observed in Mouse Model for Acquired Aplastic Anemia. CELLS, v. 11, n. 14, p. 17-pg., 2022-07-01. (14/02768-6)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

GONZAGA, Vivian Fonseca. Immature stem cells from human dental pulp: a new therapeutic strategy for the treatment of bone marrow suppression in an animal model.. 2016. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.