Does Caveolin-1 (Cav-1) modulate arrhythmogenecity by regulating cSrc tyrosine kinase and cardiac gap junction homeostasis? Role of thyroid hormone

• Grant number: 14/21464-8
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)
• Start date: March 01, 2015
• End date: December 15, 2015
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Maria Luiza de Morais Barreto de Chaves
• Grantee: Ivson Bezerra da Silva
• Supervisor: Marcelo G. Bonini
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: University of Illinois at Chicago (UIC), United States
• Associated to the scholarship: 13/04703-6 - Subcellular renin angiotensin system as mediator of the cardioprotective effector of thyroid hormone in ischemia reperfusion model, BP.DD

Abstract

The heart corresponds to main target of TH and many of the classic signs and symptoms of hyperthyroidism are the cardiac and hemodynamic manifestations which include heart rhythm disorders. The present study has as aim to define the role of Caveolin-1 (Cav-1) depletion and oxidative stress in the pro-arrhythmic effects of hyperthyroidism. We will define whether Cav-1 deletion in mice leads to arrhythmias, will define in vitro whether cardiac myocytes exposed to high levels of thyroid hormone lose Cav-1 expression and by what mechanisms and integrate both approaches by examining whether intervening on the Cav-1/c-Src pathway can preserve adequate cardiac function in mice despite of elevated thyroid hormone levels. This last piece of the work being of very high clinical relevance. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MCCAULEY, MARK D.; HONG, LIANG; SRIDHAR, ARVIND; MENON, AMBILI; PERIKE, SRIKANTH; ZHANG, MEIHONG; DA SILVA, IVSON BEZERRA; YAN, JIAJIE; BONINI, MARCELO G.; AI, XUN; et al. Ion Channel and Structural Remodeling in Obesity-Mediated Atrial Fibrillation. CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, v. 13, n. 8, AUG 2020. (14/21464-8)