Long noncoding RNAs as potential biomarkers of arthritis

• Grant number: 14/19323-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2014
• End date: October 31, 2015
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Helder Takashi Imoto Nakaya
• Grantee: Gustavo Rodrigues Ferreira
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 12/19278-6 - Systems biology of long non-coding RNAs, AP.JP

Abstract

Arthritis is an inflammatory disease whose molecular mechanisms are not yet fully understood. Several microarray studies have been carried out in an attempt to clarify the regulatory pathways involved in it, and the generated data were uploaded to a public databank. Long non-coding RNAs play crucial roles in regulating gene expression in eukaryotes. Here we propose to analyze the available microarray data in order to assess the role of lncRNAs in arthritis. To this end, we will identify lncRNAs which are differentially expressed in arthritis and the gene modules to which they may regulate. The robustness of the results will be evaluated using independent arthritis studies not previously analyzed.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERREIRA, GUSTAVO RODRIGUES; NAKAYA, HELDER IMOTO; COSTA, LUCIANO DA FONTOURA. Gene regulatory and signaling networks exhibit distinct topological distributions of motifs. Physical Review E, v. 97, n. 4, APR 27 2018. (14/19323-7, 12/19278-6, 15/22308-2)

FERREIRA, GUSTAVO RODRIGUES; NAKAYA, HELDER IMOTO; COSTA, LUCIANO DA FONTOURA. Gene regulatory and signaling networks exhibit distinct topological distributions of motifs. PHYSICAL REVIEW E, v. 97, n. 4, p. 6-pg., 2018-04-27. (14/19323-7, 15/22308-2, 12/19278-6)

RUSSO, PEDRO S. T.; FERREIRA, GUSTAVO R.; CARDOZO, LUCAS E.; BUERGER, MATHEUS C.; ARIAS-CARRASCO, RAUL; MARUYAMA, SANDRA R.; HIRATA, THIAGO D. C.; LIMA, DIOGENES S.; PASSOS, FERNANDO M.; FUKUTANI, KIYOSHI F.; et al. CEMiTool: a Bioconductor package for performing comprehensive modular co-expression analyses. BMC Bioinformatics, v. 19, FEB 20 2018. (15/25825-8, 13/08216-2, 12/19278-6, 14/19323-7, 14/24162-2, 17/05762-7, 15/20897-0)