Analysis of the immune response, lung function and maximal aerobic power of passive smokers before and after cessation of exposure to secondhand smoke

• Grant number: 14/08950-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: November 01, 2014
• End date: August 31, 2016
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Dionei Ramos
• Grantee: Gabriel Faustino Santa Brígida
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
• Associated scholarship(s): 15/11876-0 - The role of personal behaviors, exposure to tobacco smoke, and genetic factors on the low back pain: Insight from a twins study., BE.EP.MS

Abstract

Introduction: Secondhand smoke is the third leading cause of preventable death in the world and is considered an important public health problem. It is estimated that one third of the world population involuntarily inhale cigarette smoke, which can cause adverse effects such as deregulation in the immune response, reduced lung function and decrease maximal aerobic power. However, the literature remains limited regarding the effects that the cessation of exposure to secondhand smoke may promote in adults passive smokers, considering the parameters cited. Objectives: To analyze the immune response, pulmonary function and maximal aerobic power of adults passive smokers apparently healthy before and after cessation of exposure to secondhand smoke. Methods: Will be invited to participate in the study 94 subjects will be divided into two groups: passive smokers, comprised of healthy adult subjects, nonsmokers (n = 47); and control group consisted of healthy individuals with no history of exposure to secondhand smoke (n = 47). All subjects will be assessed in three moments: M0 (baseline), after four and eight weeks of cessation of exposure to secondhand smoke, M1 and M2, respectively, relative to the immune response (inflammatory markers), lung function (spirometry) and power maximal aerobic (VO2 max), as well as answer a questionnaire investigation of exposure to cigarette smoke. Statistical analysis: The data normality will be assessed by the Shapiro-Wilk test. The comparison between groups for all variables will be through the unpaired T test or Mann-Whitney test, depending on data distribution. The significance level is 5%. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BRÍGIDA, Gabriel Faustino Santa. Risk factors for respiratory and musculoskeletal disorders: the role of passive smoking and low back pain. 2016. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências e Tecnologia. Presidente Prudente Presidente Prudente.