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Influence of power low laser in ossification in rats smokers LIABILITIE: immunohistochemical study

Grant number: 16/21639-8
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2016
Effective date (End): November 30, 2017
Field of knowledge:Health Sciences - Dentistry - Orthodontics
Principal Investigator:Maria Bernadete Sasso Stuani
Grantee:Laura Cacheta Waldemarin
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


The harmful effects of cigarette smoke are not limited to the body smoker individual. Nicotine, because of its toxic effects, causes serious changes bone metabolism and can damage the alveolar bone repair. Low level laser therapy power (LBP) exhibits anti-inflammatory and analgesic effects in addition to modulate repair tissue, accelerating healing and improving the process of bone repair. Objective: To evaluate the influence of cigarette smoke on the application of low power laser on remodeling bone after tooth extraction in rats. Methods: A total of 60 Wistar rats will be randomly divided into four groups: control group (n = 15) animals with extraction Dental (Ex), Experimental Group I (n = 15) animals with Ext and application of LBP Group Experimental II (n = 15) animals with Ext and the presence of cigarette smoke (FC), Group Experimental III (n = 15) animals with Ext, presence of FC and application of LBP. The LBP is applied in the first three days (54J / cm²). Each group will be divided into 3 periods Experimental evaluation and the animals of each subgroup sacrificed at 5, 15 and 20 days after tooth extraction. They will be evaluated protein expression of TRAP, RANK-L and osteoprotegerin (OPG). The results are grouped according to the different groups of study and trial, subjected to analysis of variance and compared by t test Student. The difference is considered statistically significant at p <0.05. (AU)

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