Analysis of PLAG1 expression in pleomorphic adenoma and carcinoma ex pleomorphic adenoma

• Grant number: 14/18312-1
• Support type: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): November 01, 2014
• Effective date (End): October 31, 2015
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal researcher: Fernanda Viviane Mariano Brum Corrêa
• Grantee: Beatriz Samara de Brito
• Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Pleomorphic adenoma (PA), is the most common salivary gland neoplasm, corresponding to about 60% of all neoplasms. Although most cases are surgically removed by radical resection, recurrences may occur even after several decades and in some cases malignant transformation may still occur of a pre-existing PA causing the carcinoma ex pleomorphic adenoma (CXPA). CXPA, although relatively rare, reserve a poor prognosis and it has an aggressive clinical course, may lead to metastasis and death. Intensive studies have been conducted to identify cytogenetic alterations involving PA and CXPA for tumoral characterization and trying improve the knowledge about carcinogenesis. Strong correlation has been described between both neoplasia and the proto-oncogene PLAG1 (Pleomorphic Adenoma Gene 1). The PLAG1 gene activation leads to the production of a protein that positively regulates several genes that are growth factors and significantly contribute to tumor development. The aim of this study is to analyze the expression of PLAG1 protein in PA, residual PA and CXPA (divided according to histopathological subtype and invasiveness degree) by immunohistochemical reaction. The PLAG1 expression analysis in both tumors will help in the confirmation this marker for the diagnosis of PA and CXPA. Besides, it will help in the malign genotypic understanding according to subytpes and invasiveness degrees that this tumor presents, contributing also for the CXPA carcinogenesis study. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE BRITO, BEATRIZ SAMARA; GIOVANELLI, NATALIA; EGG, ERIKA SAID; SANCHEZ-ROMERO, CELESTE; DO NASCIMENTO, JULIANA DE SOUZA; MARTINS, ANTONIO SANTOS; TINCANI, ALFIO JOSE; DEL NEGRO, ANDRE; GONDAK, ROGERIO DE OLIVEIRA; DE ALMEIDA, OSLEI PAES; KOWALSKI, LUIZ PAULO; ALTEMANI, ALBINA; MARIANO, FERNANDA VIVIANE. Loss of expression of Plag1 in malignant transformation from pleomorphic adenoma to carcinoma ex pleomorphic adenoma. HUMAN PATHOLOGY, v. 57, p. 152-159, NOV 2016. Web of Science Citations: 9.