Evaluation of gradient flow analysis as calibration strategy for spectroanalytical techniques with plasma source

• Grant number: 14/18393-1
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: January 01, 2015
• End date: December 31, 2017
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Joaquim de Araújo Nóbrega
• Grantee: Alex Virgilio
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

Gradient flow analysis (GFA) is a novel calibration method that can improve the precision, accuracy and sample throughput for spectroanalytical instrumental techniques. The GFA method simultaneously combines the advantages of calibration by standard additions and internal standardization with the sample throughput of flow analysis. The use of GFA is simple because it does not require a series of calibration standard solutions to be prepared. Instead, only two solutions are prepared: standards + sample (1:1 v/v, solution A) and blank + sample (1:1 v/v, solution B). When solution A is introduced, the transient analytical signals for the analytes and the internal standard rise until they reach a plateau region. When solution B is mixed with solution A, the gradual dilution of the analytes and the internal standard results in signals decrease, followed by the formation of another lower intensity plateau. As the amount of sample is not changed, since both solutions contain 50% v/v of it, a matrix matching effect is obtained like in the standard additions method. By plotting the analyte-to-internal standard signal ratio (SA/SIS) in function of the inverse of the internal standard concentration (1/CIS), the analytes' concentrations can be determined by the slope-to-intercept ratio (slope / intercept) of that curve. The GFA is fast and requires no instrumental modifications or any other analytical strategy. This method can be applied to any multielement analytical technique that employs a continuous sample introduction system. In this context, this research plan proposes the evaluation of GFA for inductively coupled plasma optical emission (ICP OES) and mass spectrometry (ICP-MS). It is also proposed the evaluation of GFA in microwave induced plasma optical emission spectrometry (MIP OES) to overcome matrix interference issues.

Scientific publications

(16)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FORTUNATO, FELIPE M.; BECHLIN, MARCOS A.; GOMES NETO, JOSE A.; VIRGILIO, ALEX; DONATI, GEORGE L.; JONES, BRADLEY T.. Standard dilution analysis in flow system: Sodium determination by flame atomic emission spectrometry. Microchemical Journal, v. 124, p. 662-667, JAN 2016. (14/18393-1, 14/12595-1, 12/23323-7)

VIRGILIO, ALEX; GONCALVES, DANIEL A.; MCSWEENEY, TINA; GOMES NETO, JOSE A.; NOBREGA, JOAQUIM A.; DONATI, GEORGE L.. Multi-energy calibration applied to atomic spectrometry. Analytica Chimica Acta, v. 982, p. 31-36, AUG 22 2017. (14/18393-1)

RAQUEL C. MACHADO; ALEX VIRGILIO; CLARICE D. B. AMARAL; DANIELA SCHIAVO; JOAQUIM A. NÓBREGA; ANA RITA A. NOGUEIRA. Evaluation of Inductively Coupled Plasma Tandem Mass Spectrometry for Determination of As in Agricultural Inputs with High REE Contents. Journal of the Brazilian Chemical Society, v. 27, n. 11, p. 2076-2081, 2016-11-00. (15/14488-0, 14/18393-1, 13/26672-5)

VIRGILIO, ALEX; SCHIAVO, DANIELA; NOBREGA, JOAQUIM A.; DONATI, GEORGE L.. Evaluation of standard dilution analysis (SDA) of beverages and foodstuffs by ICP OES. Journal of Analytical Atomic Spectrometry, v. 31, n. 6, p. 1216-1222, JUN 2016. (14/18393-1)

VIRGILIO, ALEX; AMAIS, RENATA S.; AMARAL, CLARICE D. B.; FIALHO, LUCIMAR L.; SCHIAVO, DANIELA; NOBREGA, JOAQUIM A.. Reactivity and analytical performance of oxygen as cell gas in inductively coupled plasma tandem mass spectrometry. SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY, v. 126, p. 31-36, DEC 1 2016. (14/18393-1, 13/26857-5)

BARROS, JUAN A. V. A.; VIRGILIO, ALEX; SCHIAVO, DANIELA; NOBREGA, JOAQUIM A.. Determination of ultra-trace levels of Mo in plants by inductively coupled plasma tandem mass spectrometry (ICP-MS/MS). Microchemical Journal, v. 133, p. 567-571, JUL 2017. (14/18393-1)

BABOS, DIEGO VICTOR; VIRGILIO, ALEX; COSTA, VINICIUS CAMARA; DONATI, GEORGE LUIS; PEREIRA-FILHO, EDENIR RODRIGUES. Multi-energy calibration (MEC) applied to laser-induced breakdown spectroscopy (LIBS). Journal of Analytical Atomic Spectrometry, v. 33, n. 10, p. 1753-1762, OCT 1 2018. (14/18393-1, 16/01513-0)

SPERANCA, MARCO AURELIO; VIRGILIO, ALEX; PEREIRA-FILHO, EDENIR RODRIGUES; BATISTA DE AQUINO, FRANCISCO WENDEL. Determination of Elemental Content in Solder Mask Samples Used in Printed Circuit Boards Using Different Spectroanalytical Techniques. Applied Spectroscopy, v. 72, n. 8, p. 1205-1214, AUG 2018. (14/18393-1, 13/04688-7, 16/01513-0)

VIEIRA, ALAN L.; GONCALVES, DANIEL A.; VIRGILIO, ALEX; FERREIRA, EDILENE C.; JONES, BRADLEY T.; DONATI, GEORGE L.; GOMES NETO, JOSE A.. Multi-energy calibration for the determination of non-metals by high-resolution continuum source molecular absorption spectrometry. Journal of Analytical Atomic Spectrometry, v. 34, n. 5, p. 972-978, MAY 1 2019. (14/18393-1)

VIRGILIO, ALEX; NOBREGA, JOAQUIM A.; DONATI, GEORGE L.. Multi-isotope calibration for inductively coupled plasma mass spectrometry. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. 410, n. 3, p. 1157-1162, JAN 2018. (14/18393-1)

VIRGILIO, ALEX; AMAIS, RENATA STABILE; SCHIAVO, DANIELA; GOMES NETO, JOSE ANCHIETA; NOBREGA, JOAQUIM DE ARAUJO. Elemental Analysis of Phytotherapeutic Products by Inductively Coupled Plasma-Tandem Mass Spectrometry. Analytical Letters, v. 50, n. 5, p. 842-852, 2017. (13/26857-5, 14/18393-1)

VIRGILIO, ALEX; AMAIS, RENATA S.; SCHIAVO, DANIELA; NOBREGA, JOAQUIM A.. Dilute-and-Shoot Procedure for Determination of As, Cr, P, Pb, Si, and V in Ethanol Fuel by Inductively Coupled Plasma Tandem Mass Spectrometry. ENERGY & FUELS, v. 29, n. 7, p. 4339-4344, JUL 2015. (14/18393-1, 13/26857-5)

AMARAL, CLARICE D. B.; MACHADO, RAQUEL C.; VIRGILIO, ALEX; SCHIAVO, DANIELA; NOGUEIRA, ANA RITA A.; NOBREGA, JOAQUIM A.. Critical evaluation of internal standardization in ICP tandem mass spectrometry and feasibility of the oxygen reaction for boron determination in plants. Journal of Analytical Atomic Spectrometry, v. 31, n. 6, p. 1179-1184, JUN 2016. (13/26672-5, 14/18393-1, 15/14488-0)

MIRANDA, KELBER; VIEIRA, ALAN LIMA; BECHLIN, MARCOS ANDRE; FORTUNATO, FELIPE MANFROI; VIRGILIO, ALEX; FERREIRA, EDILENE CRISTINA; GOMES NETO, JOSE ANCHIETA. Determination of Ca, Cd, Cu, Fe, K, Mg, Mn, Mo, Na, Se, and Zn in Foodstuffs by Atomic Spectrometry After Sample Preparation Using a Low-Cost Closed-Vessel Conductively Heated Digestion System. FOOD ANALYTICAL METHODS, v. 9, n. 7, p. 1887-1894, JUL 2016. (14/18393-1, 12/23323-7, 14/12595-1, 12/02891-7)

VIRGILIO, ALEX; SCHIAVO, DANIELA; COSTA, LETICIA M.; NOBREGA, JOAQUIM A.; JONES, BRADLEY T.; DONATI, GEORGE L.. Inductively coupled plasma mass spectrometry and standard dilution analysis applied to concentrated acids. Talanta, v. 161, p. 826-829, DEC 1 2016. (14/18393-1)

AMARAL, CLARICE D. B.; MACHADO, RAQUEL C.; BARROS, JUAN A. V. A.; VIRGILIO, ALEX; SCHIAVO, DANIELA; NOGUEIRA, ANA RITA A.; NOBREGA, JOAQUIM A.. Determination of Rare Earth Elements in Geological and Agricultural Samples by ICP-OES. Spectroscopy, v. 32, n. 10, p. 32-36, OCT 2017. (13/26672-5, 14/18393-1, 15/14488-0)