Study of the effect of G-CSF on the generation of tolerogenic dendritic cells in vitro and the action of these cells in vivo during the clinical evolution of the Experimental Autoimmune Neuritis

• Grant number: 14/23628-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2015
• End date: October 31, 2015
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Alessandro dos Santos Farias
• Grantee: Gleici Branco
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 11/18728-5 - Study of migratory, effector and regulatory pattern of autoreactive t lymphocytes, previously transduced with GFP in experimental demyelinating diseases, AP.JP

Abstract

Guillain-Barré Syndrome is a human peripheral nervous system acute inflammatory disease. The disease may culminate in paresis of the whole patient body or even in its death.Despite the evolution of the treatment in the last decade, acute inflammatory autoimmune diseases of peripheral nervous system (PNS) are still a concern due to the considerable morbidity and mortality. The current treatment to Guillain-Barré syndrome is based on immunoglobulin (IgG) administered intravenously and/or plasma exchange. However, about 40% of the patients still need artificial ventilation or are unable to walk. Therefore, new strategies of treatment are crucial to fill the gaps of the current treatments. Experimental autoimmune neuritis (EAN), due to its wide range of similarities with GBS, the majority of scientific knowledge we have about this disorder was provided by studies in the animal model. The granulocyte-colony stumulating factor (G- CSF), has been reported to redeem an efficient role over T cells generation. In the present project, we propose the study of the effect of the G-CSF on the genaration of dendritic cells and its effector on effector function of neuritogenic cells during the clinical evolution of Experimental Autoimmune Neuritis.