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Evaluation of the repair process in rats calvarial defects with PCL and porcine collagen membrane: histometric and histological analysis

Grant number: 14/24360-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2015
Effective date (End): January 31, 2016
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal researcher:Ana Paula Farnezi Bassi
Grantee:Tamires Melo Francati
Home Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

The use of biomaterials that abet bone repair process is a field that has been explores lately, since it has been not found any biomaterial that achieve autogenous bone features. The aim of scaffolds is to hold cellular grow as well as tissue proliferation and tissue development. Recently has been developed at São Carlos (USP) a membrane of epolicraplactone fiber (PCL) that is a biodegradable polymer with a controlled degradable process, which maintain it´s structure during cell proliferation period. The aim of this research is to evaluate bone healing in critical size defect in rats, covered by PCL membrane with 5% of HA compared to porcine membrane (Bio-Guide), after 7, 15, 30, 60 days. Histological and morphometric analysis will be done to compare the potential of helping in bone repair process. Datas from histological and morphometric analysis will statistical analyzed with significance level of 5%.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FARNEZI BASSI, ANA PAULA; BIZELLI, VINICIUS FERREIRA; FRANCATTI, TAMIRES MELLO; REZENDE DE MOARES FERREIRA, ANA CARULINA; PEREIRA, JAREDE CARVALHO; AL-SHARANI, HESHAM MOHAMMED; LUCAS, FLAVIA DE ALMEIDA; FAVERANI, LEONARDO PEREZ. Bone Regeneration Assessment of Polycaprolactone Membrane on Critical-Size Defects in Rat Calvaria. MEMBRANES, v. 11, n. 2 FEB 2021. Web of Science Citations: 1.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.