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Role of omega 3 fatty acids in colon tumor

Grant number: 14/22347-5
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): March 01, 2015
Effective date (End): October 06, 2015
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:José Barreto Campello Carvalheira
Grantee:Gustavo Duarte Pimentel
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Recent studies show that colon cancer and obesity may be associated to subclinical low-grade inflammation and saturated fatty acid-induced lipotoxicity. Previous study from our laboratory demonstrated that diet-induced obesity increases the secretion of TNF inducing colon carcinogenesis (Flores et al., 2012). On the other hand, anti-inflammatory effects of Omega 3 fatty acids through both the GPR120 receptor and transgenic mouse model FAT-1 (overexpress Omega 3) on the protection of colony inflammation, our aim is to evaluate the role of Omega 3 fatty acids in the development of colon cancer in several obesity models. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MENDES, MARIA CAROLINA S.; PIMENTEL, GUSTAVO D.; COSTA, FELIPE O.; CARVALHEIRA, JOSE B. C.. Molecular and neuroendocrine mechanisms of cancer cachexia. Journal of Endocrinology, v. 226, n. 3, p. R29-R43, . (13/07607-8, 14/22347-5)

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