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Neutralizing ability of hydroalcoholic extract and two isolated phytochemicals (A and B) from Galactia glauscescens against the in vitro neuromuscular blockade-induced by Bothrops jararacussu venom

Grant number: 14/26786-3
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2015
Effective date (End): March 31, 2016
Field of knowledge:Biological Sciences - Pharmacology - Autonomic Pharmacology
Principal Investigator:Yoko Oshima Franco
Grantee:Felipe Silveira Moreno
Host Institution: Pró-Reitoria Acadêmica. Universidade de Sorocaba (UNISO). Sorocaba , SP, Brazil


One of the oldest forms of medical practice is the use of medicinal plants with phytochemicals compounds. In previous study, the protective effect of hydroalcoholic extract of Galactia glaucescens leaf was studied against Crotalus durissus terrificus venom and it was concluded that it prevents in vitro the neuromuscular blockade caused by the rattlesnake venom. Later, two phytochemicals from Galactia glaucescens extract were isolated, named here as Substance A and Substance B. The objective of this project are to evaluate the neutralizing capacity of the hydroalcoholic extract as these both isolated substances against the neuromuscular blockade induced by Bothrops jararacussu venom. The tests will be made in phrenic nerve-diaphragm preparations isolated from mice (ex vivo) and the results will be obtained by conventional miographic technique. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOS SANTOS, MARCIO G.; MORENO, FELIPE S.; DE OLIVEIRA, AKILA L.; OLIVEIRA, ISADORA C. F.; TRIBUIANI, NATALIA; COGO, JOSE C.; SCRIBONI, ANDREIA B.; COGO-MUELLER, KARINA; SAN FELICIANO, ARTURO; BONOMINI, TIAGO JOSE; et al. New pharmacological insights of Galactia glaucescens. NATURAL PRODUCT RESEARCH, v. 33, n. 16, p. 2389-2393, . (14/26786-3, 15/01420-9, 12/08271-0)

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