Synthesis of PVA-GSNO by RAFT polimerization

• Grant number: 15/04267-7
• Support Opportunities: Scholarships abroad - Research Internship - Master's degree
• Start date: August 01, 2015
• End date: January 31, 2016
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Marcelo Ganzarolli de Oliveira
• Grantee: Thatiane Cristine Camargo Marini
• Supervisor: Alexander N. Zelikin
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Institution abroad: Aarhus University, Denmark
• Associated to the scholarship: 14/03266-4 - PVA-F-127 thermosensitive nanocarriers for the photochemical nitric oxide release, BP.MS

Abstract

The main objective of this project is the synthesis of modified polyvinyl alcohol ([CH2CHOH]n, PVA) films via reversible addition fragmentation chain transfer (RAFT), which allows the inclusion of terminal amino groups at the polymer chains. The PVA-NH3 obtained will be further reacted with glutathione (GSH) via carbodiimide reaction. The terminal GSH group will be S-nitrosated to yield nitric oxide (NO)-releasing polymers (PVA-SNO). The PVA-NH2 will characterized by Nuclear Magnetic Resonance (NMR) and Gel Permeation Chromatography (GPC). The PVA-SNO films will comprise a new platform for the local delivering of NO and will be characterized regarding their NO releasing properties. (AU)