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Evaluation of tumor growth and antiangiogenic activity of pH responsive drug delivery systems containing bevacizumab: in vivo studies

Grant number: 15/04734-4
Support type:Scholarships abroad - Research Internship - Master's degree
Effective date (Start): May 01, 2015
Effective date (End): July 31, 2015
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Maria Palmira Daflon Gremião
Grantee:Natália Noronha Ferreira Naddeo
Supervisor abroad: Maria de Fátima Monginho Baltazar
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Local de pesquisa : Universidade do Minho (UMinho), Portugal  
Associated to the scholarship:13/21824-1 - PH responsive hydrogels as potential drug delivery sistem for bevacizumab administration, BP.MS


Angiogenesis process plays an important role in tumor growth, invasion and metastasis. Vascular Endothelial Growth Factor (VEGF) appears as a key in pathological situations involving neovascularization. Bevacizumab (BVZ) is a monoclonal antibody that acts against angiogenesis process which accompanies tumor tissue, resulting in inhibition of necessary supply for tumor cells development. Formulations containing antibodies represent a major challenge from a technological as biopharmaceutical point of view according their low physical and chemical stability in the formulations and biological fluids, low bioavailability and immunogenic potential, factors that requires the research for strategies to circumvent these problems. In this sense, localized therapy may allow high local concentrations and avoid technological problems relating to the stability of these agents, might reducing side effects and the need for high administration frequencies. Calcium alginate hydrogels are biocompatible systems able to interact ionically with BVZ, especially in acidic pH, like on tumor region. Thus, the use of these systems may provide an appropriate profile release of the drug across the physiological conditions of the region. During the probationary period at the Minho University, therapeutic efficacy of alginate hydrogels containing BVZ will be evaluated against biological systems using in vitro and in vivo models. (AU)