Telomere length in the central nervous system of a model of Alzheimer's Disease treated with lithium

• Grant number: 14/14211-6
• Support Opportunities: Scholarships in Brazil - Master
• Start date: April 01, 2015
• End date: March 31, 2017
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Orestes Vicente Forlenza
• Grantee: Giancarlo de Mattos Cardillo
• Host Institution: Instituto de Psiquiatria Doutor Antonio Carlos Pacheco e Silva (IPq). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Telomeres are non-coding repetitive DNA present at the end of chromosomes that get shorter with each cell division. Telomere length is considered a biological marker of age, and its shortening is shown in several age-related pathologies. In Alzheimer's disease (AD), telomeres have been associated with several pathophysiological pathways, such as neuroinflammation and oxidative stress, however its mechanisms are still poorly understood. Most of the studies about telomeres in AD were in leukocytes, few is known about its effects in the Central Nervous System (CNS). Lithium has been suggested as a possible treatment for AD. It is an important mood stabilizer and its neuroprotective effects have been widely evidenced, but few is known about its effects on telomere maintenance. This study aims to evaluate the telomere length in four CNS areas (frontal cortex, parietal cortex, hippocampus and olfactory epithelium) of an AD transgenic model mice chronically treated with different doses of lithium compared to equally treated control mice. Telomere length in DNA extracted from those tissues will be quantified by real time PCR. We expect our results to contribute to the understanding of the AD effects on different CNS regions and how they respond to lithium treatment. (AU)

Scientific publications

(11)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MÁRCIA RADANOVIC; CARLOS A. OSHIRO; THIAGO Q. FREITAS; LEDA L. TALIB; ORESTES V. FORLENZA. Correlation between CSF biomarkers of Alzheimer’s disease and global cognition in a psychogeriatric clinic cohort. Revista Brasileira de Psiquiatria, v. 41, n. 6, p. 479-484, 2019-05-30. (14/14211-6, 16/01302-9, 09/52825-8)

IBARRA, ROMEL; RADANOVIC, MARCIA; PAIS, V, MARCOS; TALIB, LEDA L.; FORLENZA, V, ORESTES. AD-Related CSF Biomarkers Across Distinct Levels of Cognitive Impairment: Correlations With Global Cognitive State. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, AUG 2020. (09/52825-8, 16/01302-9, 14/14211-6)

VACAS, SARA M.; STELLA, FLORINDO; LOUREIRO, JULIA C.; DO COUTO, FREDERICO SIMOES; OLIVEIRA-MAIA, ALBINO J.; FORLENZA, ORESTES V.. Noninvasive brain stimulation for behavioural and psychological symptoms of dementia: A systematic review and meta-analysis. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, v. 34, n. 9, SI, p. 1336-1344, SEP 2019. (16/01302-9, 09/52825-8, 14/14211-6)

DE OLIVEIRA, ALEXANDRA MARTINI; RADANOVIC, MARCIA; HOMEM DE MELLO, PATRICIA COTTING; BUCHAIN, PATRICIA CARDOSO; VIZZOTTO, ADRIANA DIAS; HARDER, JANAINA; STELLA, FLORINDO; PIERSOL, CATHERINE VERRIER; GITLIN, LAURA N.; FORLENZA, ORESTES VICENTE. An intervention to reduce neuropsychiatric symptoms and caregiver burden in dementia: Preliminary results from a randomized trial of the tailored activity program-outpatient version. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, v. 34, n. 9, p. 7-pg., 2019-09-01. (09/52825-8, 16/01302-9, 14/14211-6)

DE OLIVEIRA, ALEXANDRA MARTINI; RADANOVIC, MARCIA; HOMEM DE MELLO, PATRICIA COTTING; BUCHAIN, PATRICIA CARDOSO; VIZZOTTO, ADRIANA DIAS; HARDER, JANAINA; STELLA, FLORINDO; PIERSOL, CATHERINE VERRIER; GITLIN, LAURA N.; FORLENZA, ORESTES VICENTE. An intervention to reduce neuropsychiatric symptoms and caregiver burden in dementia: Preliminary results from a randomized trial of the tailored activity program-outpatient version. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, v. 34, n. 9, SI, p. 1301-1307, SEP 2019. (16/01302-9, 09/52825-8, 14/14211-6)

CARDILLO, GIANCARLO DE MATTOS; RODRIGUES DE-PAULA, VANESSA DE JESUS; IKENAGA, ELIZA HIROMI; COSTA, LUCIANA RODRIGUES; CATANOZI, SERGIO; SCHAEFFER, EVELIN LISETE; GATTAZ, WAGNER FARID; KERR, DANIEL SHIKANAI; FORLENZA, ORESTES VICENTE. Chronic Lithium Treatment Increases Telomere Length in Parietal Cortex and Hippocampus of Triple-Transgenic Alzheimer's Disease Mice. JOURNAL OF ALZHEIMER'S DISEASE, v. 63, n. 1, p. 93-101, 2018. (14/14211-6, 09/52825-8, 16/01302-9)

MÁRCIA RADANOVIC; CARLOS A. OSHIRO; THIAGO Q. FREITAS; LEDA L. TALIB; ORESTES V. FORLENZA. Correlation between CSF biomarkers of Alzheimer’s disease and global cognition in a psychogeriatric clinic cohort. Revista Brasileira de Psiquiatria, n. ahead, p. -, 2019. (09/52825-8, 16/01302-9, 14/14211-6)

OLIVEIRA, ALEXANDRA MARTINI; RADANOVIC, MARCIA; HOMEM DE MELLO, PATRICIA COTTING; BUCHAIN, PATRICIA CARDOSO; BARBOSA VIZZOTTO, ADRIANA DIAS; HARDER, JANAINA; STELLA, FLORINDO; GITLIN, LAURA N.; PIERSOL, CATHERINE VERRIER; VALIENGO, LEANDRO L. C.; et al. Adjunctive Therapy to Manage Neuropsychiatric Symptoms in Moderate and Severe Dementia: Randomized Clinical Trial Using an Outpatient Version of Tailored Activity Program. JOURNAL OF ALZHEIMER'S DISEASE, v. 83, n. 1, p. 475-486, 2021. (14/14211-6, 16/01302-9, 09/52825-8)

RADANOVIC, MARCIA; OSHIRO, CARLOS A.; FREITAS, THIAGO Q.; TALIB, LEDA L.; FORLENZA, ORESTES V.. Correlation between CSF biomarkers of Alzheimer's disease and global cognition in a psychogeriatric clinic cohort. Revista Brasileira de Psiquiatria, v. 41, n. 6, p. 479-484, NOV-DEC 2019. (09/52825-8, 16/01302-9, 14/14211-6)

IBARRA, ROMEL; RADANOVIC, MARCIA; PAIS, V, MARCOS; TALIB, LEDA L.; FORLENZA, V, ORESTES. AD-Related CSF Biomarkers Across Distinct Levels of Cognitive Impairment: Correlations With Global Cognitive State. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, v. 34, n. 6, SI, p. 659-667, NOV 2021. (09/52825-8, 16/01302-9, 14/14211-6)

VACAS, SARA M.; STELLA, FLORINDO; LOUREIRO, JULIA C.; DO COUTO, FREDERICO SIMOES; OLIVEIRA-MAIA, ALBINO J.; FORLENZA, ORESTES V.. Noninvasive brain stimulation for behavioural and psychological symptoms of dementia: A systematic review and meta-analysis. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, v. 34, n. 9, p. 9-pg., 2019-09-01. (16/01302-9, 14/14211-6, 09/52825-8)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CARDILLO, Giancarlo de Mattos. Telomere length in the central nervous system of a model for Alzheimer\'s disease treated with lithium. 2018. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.