Analysis of sleep pattern and cytokine secretion in leprosy patients

• Grant number: 14/27329-5
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: May 01, 2015
• End date: March 31, 2019
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Monica Levy Andersen
• Grantee: Rachel Gimenes Rodrigues Albuquerque
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated scholarship(s): 17/13999-7 - Effects of sleep fragmentation on Th1/Th2 paradigm on a murine model of leishmaniasis immune activation, BE.EP.DD

Abstract

Leprosy is a disease present since the dawn of humanity, with high rates of prevalence and incidence in countries with hot climate and considered from the third world. The United Nations annually publishes reports and promotes many programs to fight this disease so neglected and full of religious and social stigmas. The immune system of the individual is associated with the progression of the disease, so that each subtype of leprosy is related to a specific immune response patter, particularly to secretion of cytokines. These molecules are inflammatory mediators extremely important and are also related to sleep. Different studies have shown its importance in regulating the sleep-wake cycle, as well as the impact of sleep deprivation on its secretion, including favoring the pro- inflammatory state. Therefore, this study aims to evaluate the circadian rhythm of cytokines secretion and sleep pattern in patients with leprosy. For this, will be selected adult male individuals, healthy and newly diagnosed with leprosy. Both groups will undergo serial blood collection for determination of cytokines and establishment of the circadian rhythm. To evaluate sleep, the participants will fill questionnaires and will undergo polysomnography and actigraphy. We expect with this project to better understand the mechanisms involved between immunological changes and their influence on sleep, promoting a better treatment and quality of life of leprosy patients. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ALBUQUERQUE, RACHEL G.; TUFIK, SERGIO; ANDERSEN, MONICA L.. Benefits of selenium in the treatment of depression and sleep disorders Commentaries of the article ``The selenium-containing compound 3-((4-chlorophenyl)selanyl)-1-methyl-1H-indole reverses depressive-like behavior induced by acute restraint stress in mice: modulation of oxido-nitrosative stress and inflammatory pathway{''}. Sleep and Breathing, v. 23, n. 3, p. 933-934, SEP 2019. (14/27329-5)

ALBUQUERQUE, RACHEL GUIMENES; BURATTO, GABRIEL GRUEDTNER; HIROTSU, CAMILA; MAEDA, SOLANGE M.; FLORIANO, MARCOS C.; ANDERSEN, MONICA LEVY; TUFIK, SERGIO; TOMIMORI, JANE. Comparison of quality of life evaluated by SF-36 and DLQI in multibacillary and paucibacillary leprosy patients from Sao Paulo, Brazil. INTERNATIONAL JOURNAL OF DERMATOLOGY, v. 58, n. 12, p. 1415-1422, DEC 2019. (14/27329-5)

HIROTSU, CAMILA; ALBUQUERQUE, RACHEL G.; NOGUEIRA, HELOISA; HACHUL, HELENA; BITTENCOURT, LIA; TUFIK, SERGIO; ANDERSEN, MONICA L.. The relationship between sleep apnea, metabolic dysfunction and inflammation: The gender influence. BRAIN BEHAVIOR AND IMMUNITY, v. 59, p. 211-218, JAN 2017. (14/15259-2, 14/27329-5)

XERFAN, ELLEN M. S.; TOMIMORI, JANE; ALBUQUERQUE, RACHEL G.; TUFIK, SERGIO; ANDERSEN, MONICA L.. The Relationship Between Sleep and Quality of Life in Type 1 Diabetes Patients. DIABETES THERAPY, v. 10, n. 3, p. 1171-1172, JUN 2019. (14/27329-5)

ALBUQUERQUE, RACHEL G.; TUFIK, SERGIO; ANDERSEN, MONICA L.. Benefits of selenium in the treatment of depression and sleep disorders Commentaries of the article "The selenium-containing compound 3-((4-chlorophenyl)selanyl)-1-methyl-1H-indole reverses depressive-like behavior induced by acute restraint stress in mice: modulation of oxido-nitrosative stress and inflammatory pathway". Sleep and Breathing, v. 23, n. 3, p. 2-pg., 2019-09-01. (14/27329-5)