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Assessment of effects of night work in the levels of inflammatory cytokines, melatonin and cortisol in saliva

Grant number: 11/10503-4
Support type:Regular Research Grants
Duration: September 01, 2011 - August 31, 2012
Field of knowledge:Health Sciences - Collective Health - Public Health
Principal researcher:Frida Marina Fischer
Grantee:Frida Marina Fischer
Home Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Pedro Augusto Carlos Magno Fernandes ; Regina Pekelmann Markus


Despite its relevance for the economic development and widespread occurrence in modern societies, night work contributes to social impairments and health hazards for workers. Night work affects particularly rhythmic neuroendocrine systems like those controlling the secretion of melatonin and cortisol. Based on this evidence, one of the key ergonomic recommendations is to avoid night work as much as possible, what is accomplished by the implementation of rotating shifts. In Brazil, however, many companies adopt fixed shift schedules, submitting part of its workers to permanent night work. Although limited, there is some evidence pointing to a disturbance of the inflammatory cytokines production, either due to sleep deprivation, commonly observed among night workers, or to a disruption of the interaction between the circadian and immune systems. The scarcity of available data on the effect of night work on the immune system and the adoption of fixed night shifts schedules by many Brazilian companies, contrary to the ergonomic recommendations, motivated the development of this study. Therefore, based on chosen biomarkers, this work will investigate possible health effects from night work among workers of a welding industry. For the quantification of cytokines and hormones we will collect saliva from night workers and a control group at the same selected times of three working days. We will evaluate the association of biomarkers with themselves and also with the work shift. We will also test the association of the biomarkers with sleep deprivation, measured by actimetry, and perceived subjective sleepiness during worked night shifts. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
REINHARDT, ERICA LUI; CARLOS MAGNO FERNANDES, PEDRO AUGUSTO; MARKUS, REGINA P.; FISCHER, FRIDA MARINA. Night work effects on salivary cytokines TNF, IL-1 beta and IL-6. CHRONOBIOLOGY INTERNATIONAL, v. 36, n. 1, p. 11-26, JAN 2 2019. Web of Science Citations: 4.
REINHARDT, ERICA LUI; FERNANDES, PEDRO A. C. M.; MARKUS, REGINA P.; FISCHER, FRIDA MARINA. Short sleep duration increases salivary IL-6 production. CHRONOBIOLOGY INTERNATIONAL, v. 33, n. 6, SI, p. 780-782, 2016. Web of Science Citations: 2.

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