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Early detection of hypocalcemia after total thyroidectomy

Grant number: 14/18731-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2015
Effective date (End): April 30, 2016
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:José Vicente Tagliarini
Grantee:Gustavo Gonçalves Yogolare
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Hypocalcemia, after undergoing total thyroidectomy and parathyroidectomy, is the main factor that implies longer a patient stays in the hospital. The dosage of parathyroid hormone (PTH), during the surgical procedure and is widely used to determine the success of parathyroidectomy in patients with hyperparathyroidism. The aim of this study is the early identification of patients who underwent total thyroidectomy or aggregation of prior thyroidectomy hypocalcemia develop, using the dosage of PTH postoperatively and the curve of serum calcium concentration in the first 24 hours after surgery. Patients will undergo blood sampling for measurement of serum calcium and PTH, the day before surgery. Additionally, new PTH dosages will be held 8 hours after surgery, and calcium with 8, 14 and 20 hours after surgery. Subsequently, patients were reassessed after 7 and 30 days and six months, with calcium and PTH, classifying them as normal, carriers of transient or permanent (hypoparathyroidism) hypocalcemia.

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