Pal-KTTKS Peptide-Cubosome Loaded Bacterial Cellulose Masks: A Multifunctional Skin Care System

• Grant number: 14/24305-8
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: May 01, 2015
• End date: August 05, 2018
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Watson Loh
• Grantee: Seyedeh Parinaz Akhlaghi
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 17/03950-0 - Preparation of Surfactant-Free Water-in-Oil Emulsions for Cosmeceutical Applications, BE.EP.PD

Abstract

Cosmeceuticals have gained a lot of interest in the growing health industry over the past decade. The incorporation of nanotechnology in cosmeceuticals has offered new opportunities for the efficient delivery of active ingredients to the skin. Cellulose masks derived from natural resources such as bacteria have become popular in the cosmetic industry for the treatment of dry skin, due to their water retention capability, safety and biodegradability. Bacterial cellulose (BC) masks can also be loaded with active compounds such as peptides to create a more efficient skin care system. Pal-KTTKS is a pentapeptide conjugated with palmitic acid that increases collagen synthesis and can be used as an anti-aging compound. Cubosomes are submicron particles of bicontinuous cubic phases, which could be used for the incorporation of lipophilic or amphiphilic active compounds and have found numerous applications in cosmetics. This project aims at the preparation and characterization of a robust and renewable skin care system based on BC loaded with cubosomes containing Pal-KTTKS for the delivery to skin. The proposed methodology is to prepare and characterize cubosomes of phytantriol/water based on the methods present in the literature and study the in vitro loading and release of the peptide from the cubosomes. Moreover, the cubosomes will be loaded onto BC masks and the in vitro release of the active compound from the hybrid system will be compared to the peptide loaded into the BC film as a control. Furthermore, the stability of the peptide loaded in the cubosomes in the BC films will be investigated and compared to the peptide loaded in the BC films. Ex vivo tests will be performed to study the efficacy of the hybrid mask in delivery of peptide to skin.

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DEL VALLE BESSONE, CAROLINA; AKHLAGHI, SEYEDEH PARINAZ; IGNACIO TARTARA, LUIS; QUINTEROS, DANIELA ALEJANDRA; LOH, WATSON; ALBERTO ALLEMANDI, DANIEL. Latanoprost-loaded phytantriol cubosomes for the treatment of glaucoma. European Journal of Pharmaceutical Sciences, v. 160, MAY 1 2021. (16/50455-2, 14/24305-8)

BRINATTI, CESAR; AKHLAGHI, SEYEDEH PARINAZ; PIRES-OLIVEIRA, RAFAEL; BERNARDINELLI, OIGRES DANIEL; BERRY, RICHARD M.; TAM, KAM CHIU; LOH, WATSON. Controlled coagulation and redispersion of thermoresponsive poly di(ethylene oxide) methyl ether methacrylate grafted cellulose nanocrystals. Journal of Colloid and Interface Science, v. 538, p. 51-61, MAR 7 2019. (14/24305-8)

AKHLAGHI, SEYEDEH PARINAZ; LOH, WATSON. Interactions and release of two palmitoyl peptides from phytantriol cubosomes. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v. 117, p. 60-67, AUG 2017. (14/24305-8, 15/25406-5)

AKHLAGHI, SEYEDEH PARINAZ; DA SILVEIRA BALESTRIN, LIA BERALDO; BRINATTI, CESAR; PIROLT, FRANZ; LOH, WATSON; GLATTER, OTTO. Preparation and Characterization of Stabilizer-Free Phytantriol-Based Water-in-Oil Internally Liquid Crystalline Emulsions. Journal of Pharmaceutical Sciences, v. 109, n. 6, p. 2024-2032, JUN 2020. (17/03950-0, 14/24305-8)

AKHLAGHI, SEYEDEH PARINAZ; RIBEIRO, IRIS RENATA; BOYD, BEN J.; LOH, WATSON. Impact of preparation method and variables on the internal structure, morphology, and presence of liposomes in phytantriol-Pluronic (R) F127 cubosomes. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 145, p. 845-853, SEP 1 2016. (14/24305-8)