Biomimetic system structured from ionotropic gelation with bacterial cellulose nanocrystals adsorption

• Grant number: 19/22626-5
• Support Opportunities: Scholarships abroad - Research Internship - Master's degree
• Start date: December 16, 2019
• End date: March 15, 2020
• Field of knowledge: Engineering - Chemical Engineering
• Principal Investigator: Angela Faustino Jozala
• Grantee: Victória Soares Soeiro
• Supervisor: Francisco Miguel Portela da Gama
• Host Institution: Pró-Reitoria de Pós-Graduação, Pesquisa, Extensão e Inovação. Universidade de Sorocaba (UNISO). Sorocaba , SP, Brazil
• Institution abroad: Universidade do Minho (UMinho), Portugal
• Associated to the scholarship: 18/10508-5 - Production of bacterial cellulose nanocrystals for the stabilization of nanoemulsions and transepithelial transport of drugs, BP.MS

Abstract

Surfactant-free nanostructured systems have pharmacotechnical and biopharmaceutical advantages, being a green process. One of the bioproducts that can be applied to these systems are cellulose nanocrystals (NCC), derived from bacterial cellulose. Bacterial cellulose is produced extracellular by the bacterium Gluconacetobacter xylinus. It is an easily produced, non-toxic, biocompatible bioproduct with high chemical purity, crystallinity and low cost. Due to all these aspects, the present work will study the application of NCC in biomimetic systems based on ionotropic gelation for the controlled release of drugs. For this, the bacterial cellulose will be obtained through the cultivation of the bacterium G. xylinus. The NCC will be formed with the methodology developed in the master's project. Drug-containing formulations will be developed. Samples will be evaluated by SEM, confocal microscopy, FTIR, nanosizer, XRD and Liquid chromatography-mass spectrometry. The expected results are the application of NCC in new biomimetic systems, incorporating drugs and ensuring better performance. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERNANDES, ANA I.; JOZALA, ANGELA F.. Polymers Enhancing Bioavailability in Drug Delivery. PHARMACEUTICS, v. 14, n. 10, p. 7-pg., 2022-10-01. (19/22626-5, 16/05930-4)

SOEIRO, VICTORIA SOARES; SILVA-CARVALHO, RICARDO; MARTINS, DANIELA; PARPOT, PIER; GROTTO, DENISE; CHAUD, MARCO VINICIUS; PORTELA DA GAMA, FRANCISCO MIGUEL; JOZALA, ANGELA F.. Alginate-amphotericin B nanocomplexes covered by nanocrystals from bacterial cellulose: physico-chemical characterization and in vitro toxicity. SCIENTIFIC REPORTS, v. 11, n. 1, DEC 14 2021. (19/22626-5, 18/10508-5)