Polymorphism analysis of extracellular matrix genes in anterior cruciate ligament injury

• Grant number: 15/02285-8
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: June 01, 2015
• End date: March 31, 2018
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Moises Cohen
• Grantee: Leonor Isabel Casilla Loyola
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated research grant: 12/07721-2 - Sports related orthopedic conditions: clinical, genetic and molecular aspects, AP.TEM

Abstract

The musculoskeletal conditions are the most common cause of prolonged chronic pain and physical incapacity, and they affect all ages and genders and it is found in all socio-demographic classes. In the last decade, it had been reported that regular practice of sports and physical activity has a positive effect on welfare and health. However, the physical or sport practices are also associated with the risk of lesions and related sequelae. Although both diseases present a genetic component, the etiology of these diseases are still unknown. Thus, this study aim to identify polymorphisms associated with the risk of anterior cruciate ligament injury. Polymorphism of genes involved, mainly, in the extracellular matrix structure and remodeling will be analyzed to identify genetic variants associated with the risk of this lesion. To our knowledge, few studies evaluated the polymorphism in the anterior cuciate ligament injury. The investigation of genetic mechanisms may help in the improvement of prognosis determination and of patient management. This study will generate new biological information that will allow the better understanding of anterior cruciate ligament injury etiopathology with possible medicine application. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FIGUEIREDO, EDUARDO A.; LOYOLA, LEONOR CASILLA; BELANGERO, PAULO S.; CAMPOS RIBEIRO-DOS-SANTOS, ANDREA KELY; BATISTA SANTOS, SIDNEY EMANUEL; COHEN, CARINA; WAJNSZTEJN, ANDRE; DE OLIVEIRA, ADRIELLE MARTINS; SMITH, MARILIA C.; POCHINI, ALBERTO DE CASTRO; et al. Rotator Cuff Tear Susceptibility Is Associated With Variants in Genes Involved in Tendon Extracellular Matrix Homeostasis. JOURNAL OF ORTHOPAEDIC RESEARCH, v. 38, n. 1, SI, p. 192-201, JAN 2020. (11/22548-2, 12/14768-5, 13/23332-9, 15/02285-8)

COHEN, CARINA; LEAL, MARIANA F.; LOYOLA, LEONOR C.; SANTOS, SIDNEY E. B.; RIBEIRO-DOS-SANTOS, ANDREA K. C.; BELANGERO, PAULO S.; FIGUEIREDO, EDUARDO A.; WAJNSZTEJN, ANDRE; DE OLIVEIRA, ADRIELLE M.; SMITH, MARILIA C.; et al. Genetic variants involved in extracellular matrix homeostasis play a role in the susceptibility to frozen shoulder: A case-control study. JOURNAL OF ORTHOPAEDIC RESEARCH, v. 37, n. 4, p. 948-956, APR 2019. (11/22548-2, 12/14768-5, 13/23332-9, 15/02285-8)

FIGUEIREDO, EDUARDO A.; LOYOLA, LEONOR CASILLA; BELANGERO, PAULO S.; CAMPOS RIBEIRO-DOS-SANTOS, ANDREA KELY; BATISTA SANTOS, SIDNEY EMANUEL; COHEN, CARINA; WAJNSZTEJN, ANDRE; DE OLIVEIRA, ADRIELLE MARTINS; SMITH, MARILIA C.; POCHINI, ALBERTO DE CASTRO; et al. Rotator Cuff Tear Susceptibility Is Associated With Variants in Genes Involved in Tendon Extracellular Matrix Homeostasis. JOURNAL OF ORTHOPAEDIC RESEARCH, v. 38, n. 1, p. 10-pg., 2020-01-01. (15/02285-8, 11/22548-2, 13/23332-9, 12/14768-5)