Synthesis, characterization and antibacterial assays of new Ag(I) and Cu(II) complexes with acetazolamide

• Grant number: 15/09531-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2015
• End date: June 30, 2016
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Pedro Paulo Corbi
• Grantee: Caroline Santos Andrade
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

In the last years, the indiscriminate use of medicines and the constant act of self-medication increased the concern about the existence of multi-resistant bacteria to the antibiotics. So, the studies on synthesis of new metallopharmaceutical agents that may have more efficacy than those used in the clinics are of great interest. In this context, the sulfa drugs become even more interesting, especially due to its bacteriostatic activities and the number of new compounds that can be created from them, such as the metallic complexes. In this subject, two elements deserve attention by their antimicrobial activities: copper and silver. This project aims to synthesize and characterize new complexes of silver(I) and copper(II) with acetazolamide and the study of the antibacterial activity of such compounds over Gram-positive and Gram-negative bacterial strains.