| Grant number: | 15/07509-1 |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| Start date: | October 01, 2015 |
| End date: | September 30, 2016 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry - Organic Chemistry |
| Principal Investigator: | Antonio Carlos Bender Burtoloso |
| Grantee: | Barbara Bernardim de Souza |
| Supervisor: | Gonçalo José Lopes Bernardes |
| Host Institution: | Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil |
| Institution abroad: | University of Cambridge, England |
| Associated to the scholarship: | 12/22274-2 - Study in the photochemical Wolff rearrangement from a,b-unsaturated diazoketones. Aplication in diversity synthesis of nitrogen and oxygen heterocycles, BP.DR |
Abstract This project aims at applying the knowledge on the chemistry of alpha,beta-unsaturated diazoketones, developed in our group, to enable the site-selective modification of proteins in collaboration with Prof. Gonçalo Bernardes at University Of Cambridge, UK. Chemical protein modification has emerged as an invaluable tool for understanding natural systems, create therapeutic conjugates with improved performances, as well as novel protein constructs with desired properties or functions. We intend to address this challenge by employing our recently developed strategy to the synthesis of the nitroxide JP4-039 from ±,²-unsaturated diazoketones to perform chemical modification of proteins (and thus tailor their properties). (AU) | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
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