Development of library of heterocyclic fragments based on new heteroaromatic cores

• Grant number: 15/06588-5
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: July 01, 2015
• End date: January 31, 2019
• Field of knowledge: Health Sciences - Pharmacy
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Flavio da Silva Emery
• Grantee: Fernando Fumagalli
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated scholarship(s): 16/24448-9 - Ruthenium-catalyzed site selective C-H activation reactions in heteroarenes, BE.EP.DR

Abstract

It is clear the need for development of new drugs. Although, the increasing knowledge of the macromolecular mechanisms of several diseases allowed the identification of therapeutic targets, the development of drugs for these targets did not follow the same rate. Nowadays, the fast and efficient development of new drugs have been reached by used of Fragment-Based Drug Discovery (FBDD) strategies, which from a screened fragment with low potency (mM) a lead compound is obtained by optimization process. Many methodologies are being used to screening fragments considering the biological activity and drug-like characteristics. For this, the heteroaromatics compounds highlight as good fragments because of their physicochemical and electronic proprieties. Therefore, our work aim, using synthesis and chemical exploration of new heteroaromatic cores, obtain a library of fragments to use in development of bioactive compounds. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CALIL, FELIPE A.; DAVID, JULIANA S.; CHIAPPETTA, ESTELA R. C.; FUMAGALLI, FERNANDO; MELLO, RODRIGO B.; LEITE, FRANCO H. A.; CASTILHO, MARCELO S.; EMERY, FLAVIO S.; CRISTINA NONATO, M.. Ligand-based design, synthesis and biochemical evaluation of potent and selective inhibitors of Schistosoma mansoni dihydroorotate dehydrogenase. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 167, p. 357-366, APR 1 2019. (15/25099-5, 17/21146-4, 15/06588-5)

FUMAGALLI, FERNANDO; EMERY, FLAVIO DA SILVA. Charting the Chemical Reactivity Space of 2,3-Substituted Furo[2,3-b]pyridines Synthesized via the Heterocyclization of Pyridine-N-oxide Derivatives. Journal of Organic Chemistry, v. 81, n. 21, p. 10339-10347, NOV 4 2016. (15/06588-5, 14/50265-3)

FUMAGALLI, FERNANDO; GIL DE MELO, SHAIANI MARIA; RIBEIRO, CAMILA MARINGOLO; SOLCIA, MARIANA CRISTINA; PAVAN, FERNANDO ROGERIO; EMERY, FLAVIO DA SILVA. Exploiting the furo [2,3-b]pyridine core against multidrug-resistant Mycobacterium tuberculosis. Bioorganic & Medicinal Chemistry Letters, v. 29, n. 8, p. 974-977, APR 15 2019. (14/50265-3, 17/21146-4, 15/06588-5, 18/00163-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FUMAGALLI, Fernando. Synthesis, functionalization and bioprospection of heterocyclic fragments based on underexplored heteroaromatic cores. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.