Dengue fever, a disease caused by one of four serotypes of dengue virus (DENV 1-4), which is the main arbovirus currently affects humans. Although the disease is known for over 70 years, there are no effective treatments for the disease, as well as vaccine formulations available and capable of conferring protection against the infection. Clinical tests studies indicate that induction of high titers of neutralizing antibodies is not a suitable protective correlate therefore a more detailed review of the role of cellular immunity in protection against dengue becomes particularly relevant. Thus, this project aims to explore the role of non-structural proteins of dengue virus type 2 (DENV2) in immune response induction protective cell in an experimental model. For this purpose vaccine formulations composed of three major non-structural proteins: NS1, NS3 and NS5 as recombinant proteins and DNA vaccines used in vaccine compositions for immunization in an animal model. Adaptive immune response profiles are weighed against the different protocols immunization, ensuring that the cellular profile found may be associated or not with viral protection. The knowledge generated from the research proposal will reassess the current correlates involved in protection against infection by DENV, as well as facilitate the development of effective vaccines against the disease. (AU)
News published in Agência FAPESP Newsletter about the scholarship:
DOS SANTOS ALVES, RUBENS PRINCE;
PEREIRA, SARA ARAUJO;
PEREIRA, LENNON RAMOS;
DE FREITAS, CARLA LONGO;
PEREIRA, SAMUEL SANTOS;
VENCESLAU-CARVALHO, ALEXIA ADRIANNE;
CASTRO-AMARANTE, MARIA FERNANDA;
PINHO FAVARO, MARIANNA TEIXEIRA;
AMORIM, JAIME HENRIQUE;
DE SOUZA FERREIRA, LUIS CARLOS.
Transcutaneous Administration of Dengue Vaccines.
Web of Science Citations: 0.