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Vaccines for control of dengue: vaccine potential of the combination of the non-structural proteins in the generation of protective cell response in an experimental model

Grant number: 15/02352-7
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2015
Effective date (End): October 07, 2020
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Luis Carlos de Souza Ferreira
Grantee:Rubens Prince dos Santos Alves
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):17/25166-0 - Development of an immunocompetent animal model for the study of dengue vaccines in the context of DENV-exposed and naïve groups, BE.EP.DR

Abstract

Dengue fever, a disease caused by one of four serotypes of dengue virus (DENV 1-4), which is the main arbovirus currently affects humans. Although the disease is known for over 70 years, there are no effective treatments for the disease, as well as vaccine formulations available and capable of conferring protection against the infection. Clinical tests studies indicate that induction of high titers of neutralizing antibodies is not a suitable protective correlate therefore a more detailed review of the role of cellular immunity in protection against dengue becomes particularly relevant. Thus, this project aims to explore the role of non-structural proteins of dengue virus type 2 (DENV2) in immune response induction protective cell in an experimental model. For this purpose vaccine formulations composed of three major non-structural proteins: NS1, NS3 and NS5 as recombinant proteins and DNA vaccines used in vaccine compositions for immunization in an animal model. Adaptive immune response profiles are weighed against the different protocols immunization, ensuring that the cellular profile found may be associated or not with viral protection. The knowledge generated from the research proposal will reassess the current correlates involved in protection against infection by DENV, as well as facilitate the development of effective vaccines against the disease. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ARAUJO, SERGIO C.; PEREIRA, LENNON R.; ALVES, RUBENS P. S.; ANDREATA-SANTOS, ROBERT; KANNO, ALEX I.; FERREIRA, LUIS CARLOS S.; GONCALVES, VIVIANE M. Anti-Flavivirus Vaccines: Review of the Present Situation and Perspectives of Subunit Vaccines Produced in Escherichia coli. VACCINES, v. 8, n. 3 SEP 2020. Web of Science Citations: 0.
ANDREATA-SANTOS, ROBERT; DOS SANTOS ALVES, RUBENS PRINCE; PEREIRA, SARA ARAUJO; PEREIRA, LENNON RAMOS; DE FREITAS, CARLA LONGO; PEREIRA, SAMUEL SANTOS; VENCESLAU-CARVALHO, ALEXIA ADRIANNE; CASTRO-AMARANTE, MARIA FERNANDA; PINHO FAVARO, MARIANNA TEIXEIRA; MATHIAS-SANTOS, CAMILA; AMORIM, JAIME HENRIQUE; DE SOUZA FERREIRA, LUIS CARLOS. Transcutaneous Administration of Dengue Vaccines. Viruses-Basel, v. 12, n. 5 MAY 2020. Web of Science Citations: 0.
DOS SANTOS ALVES, RBENS PRINCE; PEREIRA, LENNON RAMOS; NASCIMENTO FABRIS, DENICAR LINA; SALVADOR, FELIPE SCASSI; SANTOS, ROBERT ANDREATA; DE ANDRADE ZANOTTO, PAOLO MARINHO; ROMANO, CAMILA MALTA; AMORIM, JAIME HENRIQUE; DE SOUZA FERREIRAA, LUIS CARLOS. Production of a Recombinant Dengue Virus 2 NS5 Protein and Potential Use as a Vaccine Antigen. Clinical and Vaccine Immunology, v. 23, n. 6, p. 460-469, JUN 2016. Web of Science Citations: 4.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.