Comparative analyses of induced pluripotent stem cell-derived neurons from patients with Gaucher disease and Parkinson

• Grant number: 14/24587-3
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: August 01, 2015
• End date: July 31, 2019
• Field of knowledge: Biological Sciences - Genetics - Human and Medical Genetics
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Lygia da Veiga Pereira
• Grantee: Fabiano Tófoli de Araújo
• Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 13/08135-2 - CTC - Center for Cell-Based Therapy, AP.CEPID

Abstract

Recent works have show association of the Gaucher Disease (GD) with Parkinson's Disease (PD), where GBA mutation carriers present a higher risk of to present Parkinsonism. However, the mechanism underlying this associations is still unknown. Induced pluripotent stem cells (iPSC) are a valuable experimental system in which to studying neurodegenerative conditions with more complex genetic predisposition, as well as metabolic diseases known to have familial predispositions but for which the genetic contribution remains unexplained. Our goal is to develop iPSC from patients with PD, carriers and non-carriers of mutations in the GBA gene, in order to study their neurogenesis in vitro. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ARAÚJO, Fabiano Tófoli de. Comparative analysis of derived neurons from induced pluripotent stem cells (iPSC) to study the Gaucher disease and Parkinson\'s disease association. 2020. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Biociências (IBIOC/SB) São Paulo.