Relationship between inflammatory markers and hippocampal and extra-hippocampal atrophy patterns in patients with temporal lobe epilepsy

• Grant number: 15/17066-0
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: September 01, 2015
• End date: November 30, 2018
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Fernando Cendes
• Grantee: Marina Koutsodontis Machado Alvim
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology, AP.CEPID

Abstract

Introduction: Temporal lobe epilepsy is the most common epilepsy in tertiary centers. The disease presents worse prognosis when associated with hippocampal sclerosis. Actually it is known that the inflammatory activity is related to some neurologic diseases, including epilepsy. Probably it is associated to the increased neuronal excitability and contributes to brain damage. In 2013, ILAE (International League Against Epilepsy) defined a new classification of hippocampal sclerosis patterns in temporal lobe epilepsy. The relationship between the hippocampal and extra-hippocampal atrophy patterns and de inflammatory markers was not studied yet. Objective: Define the relationship between inflammatory markers and hippocampal and extra-hippocampal atrophy in patients with temporal lobe epilepsy. Methods: We will study temporal lobe epilepsy patients with or without hippocampal sclerosis, from neurology clinic in University of Campinas Hospital. All of them will be submitted to 3-Tesla Resonance Magnetic Imaging (MRI). The hippocampal volumetry and the sclerosis pattern, with segmentation of the hippocampal subfields, will be processed by Freesurfer software. The extra-hippocampal atrophy pattern will be defined by Voxel Based Morphometry (VBM) analysis. The inflammatory markers included, that were previously collected from patients and health controls, are IL-2, IL-4, IL-6, IL-10, TNF, IFN e IL-17. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ALVIM, MARINA K. M.; MORITA, MARCIA E.; YASUDA, CLARISSA L.; DAMASCENO, BENITO P.; LOPES, TATILA M.; COAN, ANA CAROLINA; GHIZONI, ENRICO; TEDESCHI, HELDER; CENDES, FERNANDO. Is inpatient ictal video-electroencephalographic monitoring mandatory in mesial temporal lobe epilepsy with unilateral hippocampal sclerosis? A prospective study. Epilepsia, v. 59, n. 2, p. 410-419, FEB 2018. (12/05364-8, 15/17066-0)

ALVIM, MARINA K. M.; MORITA-SHERMAN, MARCIA E.; YASUDA, CLARISSA L.; ROCHA, NATALIA P.; VIEIRA, ERICA L.; PIMENTEL-SILVA, LUCIANA R.; HENRIQUE NOGUEIRA, MATEUS; BARBOSA, RENATA; WATANABE, NANCY; COAN, ANA CAROLINA; et al. Inflammatory and neurotrophic factor plasma levels are related to epilepsy independently of etiology. Epilepsia, v. 62, n. 10, JUL 2021. (13/07559-3, 15/17066-0)

ALVIM, MARINA K. M.; COAN, ANA C.; CAMPOS, BRUNNO M.; YASUDA, CLARISSA L.; OLIVEIRA, MARIANA C.; MORITA, MARCIA E.; CENDES, FERNANDO. Progression of gray matter atrophy in seizure-free patients with temporal lobe epilepsy. Epilepsia, v. 57, n. 4, p. 621-629, APR 2016. (15/17066-0, 13/07559-3, 13/00099-7)

GLEICHGERRCHT, EZEQUIEL; MUNSELL, BRENT C.; ALHUSAINI, SAUD; ALVIM, MARINA K. M.; BARGALLO, NURIA; BENDER, BENJAMIN; BERNASCONI, ANDREA; BERNASCONI, NEDA; BERNHARDT, BORIS; BLACKMON, KAREN; et al. Artificial intelligence for classification of temporal lobe epilepsy with ROI-level MRI data: A worldwide ENIGMA-Epilepsy study. NEUROIMAGE-CLINICAL, v. 31, 2021. (13/07559-3, 15/17066-0)

HATTON, SEAN N.; HUYNH, KHOA H.; BONILHA, LEONARDO; ABELA, EUGENIO; ALHUSAINI, SAUD; ALTMANN, ANDRE; ALVIM, MARINA K. M.; BALACHANDRA, AKSHARA R.; BARTOLINI, EMANUELE; BENDER, BENJAMIN; et al. White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study. BRAIN, v. 143, n. 8, p. 20-pg., 2020-08-01. (16/16355-0, 15/17066-0, 13/07559-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ALVIM, Marina Koutsodontis Machado. The relationship between inflammatory markers and hippocampal and extra-hippocampal atrophy patterns in patients with temporal lobe epilepsy. 2019. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.