Changes on cortical neurochemistry associated with the expression of contextual conditioned tolerance of rats submitted to chronic treatment with the dissociative anesthetic ketamine

• Grant number: 15/17568-5
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): October 01, 2015
• Effective date (End): August 31, 2017
• Field of knowledge: Humanities - Psychology - Social Psychology
• Principal Investigator: Manoel Jorge Nobre Do Espirito Santo
• Grantee: Gleice Kelli Ribeiro da Silva Cardoso
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The lack of preclinical studies on the effects of ketamine, when administered continuously, as well as the possible emergence of withdrawal symptoms after the abrupt cessation of its use, are issues still little discussed in the literature. Studies in this line of research makes it even more necessary in light of the increased use among young people who, as a rule, commonly use this drug jointly with other substances, particularly with central nervous system stimulants. This project aims to fill part of this deficiency by analyzing the influence of the chronic effects of ketamine on contextual conditioned tolerance and the subjacent changes on the he neurochemical levels of 5-HT, DA and their metabolites of the infralimbic cortex and nucleus accumbens shell, brain regions mainly involved in the motivational aspects of drug use and abuse. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVA-CARDOSO, GLEICE KELLI; NOBRE, MANOEL JORGE. Context-Specific Tolerance and Pharmacological Changes in the Infralimbic Cortex-Nucleus Accumbens Shell Pathway Evoked by Ketamine. Neurochemical Research, v. 46, n. 7, MAR 2021. (15/17568-5, 17/18268-0, 14/23690-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CARDOSO, Gleice Kelli Ribeiro da Silva. Behavioral and neurochemical changes in subcortical systems underlying the context-dependent tolerance expression induced by the dissociative anesthetic ketamine. 2017. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (PCARP/BC) Ribeirão Preto.