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Study on the supramolecular interactions in silver nanoparticles and their antimicrobial activity

Grant number: 15/12534-5
Support type:Scholarships in Brazil - Master
Effective date (Start): October 01, 2015
Effective date (End): July 31, 2017
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Ljubica Tasic
Grantee:Caio Henrique Nasi de Barros
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Even being known for over a century, silver nanoparticles (AgNP) have only been explored more extensively in the last few decades in view of its potential to be applied in the biomedical and biological fields, as well as in the consumer goods sector. In this project, we intend to explore a synthetic route involving the orange peel extract in the biosynthesis of AgNP and more specifically the reduction and/or stabilizing potential of the flavonoid hesperidin. Considering that chemical and biophysical interactions of biomolecules are necessary for the stabilization of nanoparticles, several techniques will be used for the characterization of these macromolecules, such as emission fluorescence, infrared spectroscopy (IR), gel electrophoresis (SDS-PAGE), gel filtration chromatography, mass spectrometry and nuclear magnetic resonance (NMR of 1H and 13C). Finally, the antimicrobial activity of the silver nanoparticles will be studied using strains of Xanthomonas, which include bacteria responsible for agricultural pests such as the citrus canker in orange plantations, that causes large damages in the Brazilian agriculture production.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BARROS, CAIO H. N.; FULAZ, STEPHANIE; STANISIC, DANIJELA; TASIC, LJUBICA. Biogenic Nanosilver against Multidrug-Resistant Bacteria (MDRB). ANTIBIOTICS-BASEL, v. 7, n. 3 SEP 2018. Web of Science Citations: 11.
NASI DE BARROS, CAIO HENRIQUE; FARIA CRUZ, GUILHERME CRISPIM; MAYRINK, WILLIAN; TASIC, LJUBICA. Bio-based synthesis of silver nanoparticles from orange waste: effects of distinct biomolecule coatings on size, morphology, and antimicrobial activity. NANOTECHNOLOGY SCIENCE AND APPLICATIONS, v. 11, p. 1-14, 2018. Web of Science Citations: 10.
STANISIC, DANIJELA; FREGONESI, NATALIA L.; BARROS, CAIO H. N.; PONTES, JOAO G. M.; FULAZ, STEPHANIE; MENEZES, ULISSES J.; NICOLETI, JORGE L.; CASTRO, THIAGO L. P.; SEYFFERT, NUBIA; AZEVEDO, VASCO; DURAN, NELSON; PORTELA, RICARDO W.; TASIC, LJUBICA. NMR insights on nano silver post-surgical treatment of superficial caseous lymphadenitis in small ruminants. RSC ADVANCES, v. 8, n. 71, p. 40778-40786, 2018. Web of Science Citations: 1.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)

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