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Characterization of thymus during the evolution of experimental encephalomyelitis

Grant number: 15/10107-2
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): November 01, 2015
Effective date (End): September 30, 2018
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal researcher:Alessandro dos Santos Farias
Grantee:Carolina Francelin de Andrade
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:11/18728-5 - Study of migratory, effector and regulatory pattern of autoreactive t lymphocytes, previously transduced with GFP in experimental demyelinating diseases, AP.JP

Abstract

The experimental autoimmune encephalomyelitis (EAE) is a model of autoimmune disease mediated by T-lymphocytes, as these diseases can be adoptively transferred to naive animals by CD4 + T lymphocytes. The effector function of these lymphocytes may be decreased by regulatory CD4T cells. The full development of T cells depends on the continuous migration of hematopoietic precursora through the thymic microenvironment which is composed of lymphoid and non-lymphoid components. The intrathymic migration is essential for T cells to receive the necessary signs for survival, proliferation, differentiation and generation of diversity of repertoire. Considering that T cells have their origin in the thymus and that this organ is essential for the correct development of T lymphocytes and selection of autoreactive T lymphocytes, analysis of the thymus during EAE is important for a better understanding of the dysregulation of T lymphocytes found in sclerosis. Further, data from our laboratory demonstrated thymus disrupment and the existence of CD4 + CD8 + lymphocytes in the central nervous system, during the stage of disease exacerbation. In this study, we intend to characterize and evaluate the thymus thymopoiesis during and after EAE, as well as the export of immature and auto-reactive towards the periphery of immune T lymphocytes.