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Analysis of physico-chemical, mechanical and biological properties of dental acrylic resin synthesized by different methods.

Grant number: 14/25793-6
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2015
Effective date (End): January 31, 2018
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Principal researcher:Andréa Cândido dos Reis
Grantee:Denise Tornavoi de Castro
Home Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Biofilm formation on the surfaces of prosthetic devices plays an important role in development of various oral diseases. One way of overcome this problem is through the development of antimicrobial acrylic resins. The objective of this study is to propose different methods of incorporations nanostructured silver vanadate (²-AgVO3) in dental acrylic resin. Will be evaluated the standard promoted by incorporation proposed methods, the mechanical performance, antimicrobial capacity, release rate of the silver (Ag) and vanadium (V) ions and the biocompatibility of the resulting materials. The ²-AgVO3 be incorporated into the resin in the fractions of 0 - 5% by weight by three methods (I) through the use of a sonicator under different conditions of time and power, (II) the complete solubilization of the polymer before adding the nanomaterial fractions and (III) by pre-mix the polymer with ²-AgVO3 using a twin screw extruder. The physicochemical characterization of the specimens will be performed by scanning electron microscopy and microanalysis (SEM / EDS)and X-ray diffraction (XRD). The mechanical performance will be evaluated for resistance flexural and impact tests and antimicrobial capacity by biomolecular methods of PCR and genetic sequencing.The release rate of Ag and V elements will be analyzed by mass spectrometry with inductively coupled plasma (ICP-MS. The biocompatibility will be evaluated by histochemical method MTT with epithelial cells by human palate. The data will be statistically analyzed with normality and homogeneity tests to define the use of parametric or non-parametric analysis.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE CASTRO, DENISE TORNAVOI; TEIXEIRA, ANA BEATRIZ VILELA; DO NASCIMENTO, CASSIO; ALVES, OSWALDO LUIZ; DE SOUZA SANTOS, EMERSON; AGNELLI, JOSE AUGUSTO MARCONDES; DOS REIS, ANDREA CANDIDO. Comparison of oral microbiome profile of polymers modified with silver and vanadium base nanomaterial by next-generation sequencing. ODONTOLOGY, JAN 2021. Web of Science Citations: 0.
DE CASTRO, DENISE T.; KREVE, SIMONE; OLIVEIRA, VIVIANE C.; ALVES, OSWALDO L.; DOS REIS, ANDREA C. Development of an Impression Material with Antimicrobial Properties for Dental Application. JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY, v. 28, n. 8 AUG 2019. Web of Science Citations: 0.
DE CASTRO, DENISE TORNAVOI; DO NASCIMENTO, CASSIO; ALVES, OSWALDO LUIZ; SANTOS, EMERSON DE SOUZA; MARCONDES AGNELLI, JOSE AUGUSTO; DOS REIS, ANDREA CANDIDO. Analysis of the oral microbiome on the surface of modified dental polymers. ARCHIVES OF ORAL BIOLOGY, v. 93, p. 107-114, SEP 2018. Web of Science Citations: 2.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CASTRO, Denise Tornavoi de. Analysis of the physical-chemical, mechanical and biological properties of a dental acrylic resin synthesized by different methods. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Odontologia de Ribeirão Preto Ribeirão Preto.

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