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Evolution of the control pathways of tissue development in Diptera

Grant number: 15/20183-8
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): December 01, 2015
Effective date (End): January 31, 2018
Field of knowledge:Biological Sciences - Genetics - Animal Genetics
Principal Investigator:Tatiana Teixeira Torres
Grantee:Raquel Dietsche Monfardini
Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):16/10342-4 - Molecular basis of development control mediated by Ilp8 in Hermetia illucens and Drosophila melanogaster, BE.EP.MS


Larval imaginal discs are the precursors of adult organs in holometabolous insects. Hence, any damage in the discs that is not repaired would result in errors in the organ formation and may incapacitate the adult stage. Therefore, it is necessary to have control mechanisms of tissue development in larval individuals. An example of such mechanisms is the metamorphosis delay. Studies using Drosophila melanogaster larvae demonstrated that ILP8 protein is involved in this control, as its high concentrations delay the pupariationand ensure time for tissue recovery. Despite its importance, little is known about Ilp8 gene evolution among dipterans and its involvement in the metamorphosis delay. It is assumed that metamorphosis delay occurs since basal dipterans as a development control mechanism, but the Ilp8 gene is a Brachycera innovation. Moreover, it is not clear when ILP8's role in development has evolved. To understand the molecular basis and evolution of the delay mechanism, one of the best approaches is the comparison of gene expression in larvae with normal growth and larvae that had tissue damage during its development. Comparative RNA-seq assays of species with and without the Ilp8 ortholog will allow the investigation of when both, Ilp8 gene and function, has evolved. Furthermore, in species that do not have its ortholog, which genes are involved in this metabolic pathway.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MONFARDINI, Raquel Dietsche. Evolution of the control pathways of tissue development in holometabolous insects. 2018. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Biociências (IBIOC/SB) São Paulo.

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