Tridimensional printing for bone reconstruction in the radio of rabbits

• Grant number: 15/10139-1
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: December 01, 2015
• End date: February 28, 2018
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Bruno Watanabe Minto
• Grantee: Arícia Gomes Sprada
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

Tissue engineering enables the restoration of an organ or tissue damaged by diseases, trauma or even by the aging process, through a combination of cells and materials. Within this context, three-dimensional printers (3D) appear as an affordable alternative in the development of models and implants to be employed in regenerative medicine field. The purpose of this study is to use 3D printer technology to obtain bone substitutes for reconstruction of critical segmental defect in rabbits' radio. For this research, 60 New Zealand rabbits will be submitted to a segmental ostectomy on the right radio. The animals will be divided into three groups. The graft group (GI n=20) in which the animals will receive autologous graft for the bone defect reconstruction. The implant group (GII n=20) where the defect will be restored with hydroxyapatite implants printed in a three-dimensional printer and the control group (GIII n=20) where the animals will be submitted to ostectomy and receive no surgical treatment. The implants obtained by the 3D printing will be based on the CT image from the animals member (right radio). The subjects of this study will be clinically evaluated daily. Radiographs, bone densitometry and histopathological exams will be performed at the 15, 30, 60 and 90 day postoperative, according to the subgroups P1(15 days), P2 (30 days), P3 (60), P4 (90). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MINTO, BRUNO WATANABE; SPRADA, ARICIA GOMES; GONCALVES NETO, JOSE ALOIZIO; DE ALCANTARA, BRENDA MENDONCA; DE SA ROCHA, THIAGO ANDRE SALVITTI; VALENTIM HESPANHA, ANA CAROLINA; QUARTERONE, CAROLINA; SARTORI, MARESSA DA ROCHA; HATAKA, ALESSANDRE; RAMIREZ USCATEGUI, RICARDO ANDRES; et al. Three-dimensional printed poly (L-lactide) and hydroxyapatite composite for reconstruction of critical bone defect in rabbits. Acta Cirurgica Brasileira, v. 36, n. 4, 2021. (15/10139-1)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SPRADA, Arícia Gomes. 3D prototyped composite in the reconstruction of critical defects in radius of rabbits (Oryctolagus cuniculus). 2019. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.