Participation of calcium transient and their regulatory proteins in cardiac function improvements in rats with supravalvar aortic stenosis and ventricular dysfunction submitted to exercise training

• Grant number: 15/20013-5
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: January 01, 2016
• End date: September 30, 2018
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Antonio Carlos Cicogna
• Grantee: Vitor Loureiro da Silva
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Several experimental models have been proposed to study cardiac remodeling (CR); among them, the induction to supravalvar aortic stenosis (SAS). Physiopathological mechanisms responsible for cardiac function depression in this model of study are not well defined, however, there is relation to changes in intracellular calcium transient and their regulatory proteins. Calcium transient is one of the main mechanisms responsible for contraction and relaxation of myocardium; the following proteins modulate flow of intracellular calcium: L-type calcium channel, ryanodine receptor, calsequestrin, sarcoplasmic reticulum calcium pump, phospholamban, sodium/calcium exchanger and sarcolemma calcium pump.Pharmacological and non-pharmacological measures have been employed to promote attenuation of cardiac dysfunction in animals with pathological remodeling. Exercise training is considered a key intervention in preventive cardiology. Specifically, aerobic exercise training (TFa), in normal condition, enhance cardiac function associated to positive adaptations in calcium transient and their regulatory agents. In cardiac pathology motivated, among other factors, for pressure overload, studies show that exercise training restores, total or partially, cardiac function, which delays the transition to heart failure, among other factors, for promoting improvments in intracellular calcium transient of EAo rats. In order to test this premise aired, cardiac function, calcium transient and gene expression of their regulatory proteins of EAo rats submitted to exercise training will be assessed.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VITOR LOUREIRO DA SILVA; SÉRGIO LUIZ BORGES DE SOUZA; GUSTAVO AUGUSTO FERREIRA MOTA; DIJON H. S. CAMPOS; ALEXANDRE BARROSO MELO; DANIELLE FERNANDES VILEIGAS; PAULA GRIPPA SANTANA; PRISCILA MURUCCI COELHO; SILMÉIA GARCIA ZANATI BAZAN; ANDRÉ SOARES LEOPOLDO; et al. Cenário Disfuncional dos Principais Componentes Responsáveis pelo Equilíbrio do Trânsito de Cálcio Miocárdico na Insuficiência Cardíaca Induzida por Estenose Aórtica. Arquivos Brasileiros de Cardiologia, v. 118, n. 2, p. 463-475, 2022-02-28. (15/20013-5)

DA SILVA, VITOR LOUREIRO; MOTA, GUSTAVO AUGUSTO FERREIRA; DE SOUZA, SERGIO LUIZ BORGES; DE CAMPOS, DIJON HENRIQUE SALOME; MELO, ALEXANDRE BARROSO; VILEIGAS, DANIELLE FERNANDES; COELHO, PRISCILA MURUCCI; SANT'ANA, PAULA GRIPPA; PADOVANI, CARLOS; LIMA-LEOPOLDO, ANA PAULA; et al. Aerobic Exercise Training Improves Calcium Handling and Cardiac Function in Rats with Heart Failure Resulting from Aortic Stenosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 15, p. 20-pg., 2023-08-01. (15/20013-5, 15/16934-8)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SILVA, Vitor Loureiro da. Participation of the calcium handling and its regulatory proteins in the improvement of the cardiac function of rats with supravalvar aortic stenosis and ventricular dysfunction submitted to exercise training. 2019. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Medicina. Botucatu Botucatu.