Effects of excessive daytime sleepiness or insomnia associated with obstructive sleep apnea on the cardiovascular risk: a prospective longitudinal population-based study

• Grant number: 15/19136-5
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: January 01, 2016
• End date: March 31, 2018
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Monica Levy Andersen
• Grantee: Lenise Jihe Kim
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

In the last 3 decades, the prevalence of sleep disorders and sleep complaints have been increasing, including respiratory events, difficulties in falling asleep and in the sleep maintenance, and excessive daytime sleepiness (EDS). Obstructive sleep apnea (OSA), insomnia, and EDS are risk factors of cardiovascular outcomes. Nevertheless, the effects of the association among these sleep disturbances are still divergent and the methodological limitations of the studies reduce the validity of the existing findings. Our research aims to investigate the relationship between EDS or insomnia associated with OSA in the risk of cardiovascular outcomes. This study consists in a large prospective longitudinal population-based study after 8 years of patients follow-up. To evaluate the isolated effect of EDS and when associated with OSA on the cardiovascular risk, the participants from the population-based study will be distributed in the groups no-OSA without EDS, no-OSA with EDS, OSA without EDS, and OSA with EDS. To evaluate the isolated effect of insomnia and when associated with OSA on the cardiovascular risk, the participants will be distributed in the groups no-OSA without insomnia, no-OSA with insomnia, OSA without insomnia, and OSA with insomnia. The outcomes that will be evaluate comprise the mortality rate, frequency of cardiovascular events, and the profile of cardiovascular risk factors. We expect that the findings of our study indicate that, besides the isolated effect, the OSA associated with EDS or insomnia potentiates the negative effects of OSA on patients' health. This research could provide new perspectives of diagnostic and therapeutic approaches for sleep disorders, aiming to decrease the risk of cardiovascular diseases and to improve the individuals' quality of life.

Scientific publications

(21)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MORELHAO, PRISCILA K.; ANDERSEN, MONICA L.; TUFIK, SERGIO; PINTO, RAFAEL Z.. Letter to the Editor About the Article ``Aquatic Exercises in the Treatment of Low Back Pain: A Systematic Review of the Literature and Meta-Analysis of Eight Studies{''}. AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, v. 97, n. 12, p. 934-935, DEC 2018. (15/19136-5)

DE OLIVEIRA, DANIELA LEITE; DOKKEDAL-SILVA, VINICIUS; FERNANDES, GUILHERME LUIZ; KIM, LENISE JIHE; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. Sleep duration as an independent factor associated with vitamin D levels in the EPISONO cohort. JOURNAL OF CLINICAL SLEEP MEDICINE, v. 17, n. 12, p. 2439-2449, DEC 1 2021. (16/02205-7, 15/19136-5)

DOKKEDAL-SILVA, VINICIUS; KIM, LENISE J.; GALDUROZ, JOSE C.; TUFIK, SERGIO; ANDERSEN, MONICA L.. Cocaine use by older populations, sleep quality, and associated risks. Revista Brasileira de Psiquiatria, v. 40, n. 4, p. 459, OCT-DEC 2018. (15/19136-5)

DOKKEDAL-SILVA, VINICIUS; KIM, LENISE JIHE; MORELHAO, PRISCILA KALIL; FERNANDES GALDUROZ, JOSE CARLOS; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. Use of clonazepam in REM sleep behavior disorder: association with fall-related injuries and alternative treatments. JOURNAL OF CLINICAL SLEEP MEDICINE, v. 16, n. 4, p. 655-656, APR 15 2020. (15/19136-5)

DE OLIVEIRA, D. L.; HIROTSU, C.; KIM, L. J.; TUFIK, S.; ANDERSEN, M. L.. SLEEP DURATION AS AN INDEPENDENT FACTOR ASSOCIATED WITH VITAMIN D LEVELS IN EPISONO COHORT. Sleep, v. 41, p. 1-pg., 2018-04-01. (14/15259-2, 15/19136-5, 16/02205-7)

KIM, L. J.; BITTENCOURT, L.; TUFIK, S.; ANDERSEN, M. L.. EVALUATION OF SLEEP MISPERCEPTION SPECTRUM: FREQUENCIES AND ASSOCIATED FACTORS IN EPISONO COHORT. Sleep, v. 41, p. 1-pg., 2018-04-01. (15/19136-5)

MELLO-FUJITA, L.; KIM, L. JIHE; DUMAS CINTRA, F.; FERES, M.; LINO DE SOUZA, A.; RIZZI, C.; MAIA, K.; BRASIL, E.; OLIVEIRA, W.; TUFIK, S.; et al. SAFETY AND EFFICACY OF 6-MONTH USE OF SHAM-CPAP IN OBSTRUCTIVE SLEEP APNEA PATIENTS. Sleep Medicine, v. 40, p. 1-pg., 2017-12-01. (15/19136-5)

DE OLIVEIRA, D. L.; HIROTSU, C.; KIM, L. J.; TUFIK, S.; ANDERSEN, M. L.. SLEEP DURATION AS AN INDEPENDENT FACTOR ASSOCIATED WITH VITAMIN D LEVELS. Sleep Medicine, v. 40, p. 1-pg., 2017-12-01. (14/15259-2, 15/19136-5, 16/02205-7)

ARAUJO, P.; KIM, L. J.; PINTO-JUNIOR, L. R.; LORENZI-FILHO, G.; BACELAR, A.; TUFIK, S.; ANDERSEN, M. L.. KNOWLEDGE AND ATTITUDES TOWARDS SLEEP HABITS IN BRAZILIAN POPULATION: FINDINGS FROM WORLD SLEEP DAY. Sleep Medicine, v. 40, p. 1-pg., 2017-12-01. (14/10255-9, 15/19136-5)

KIM, L. J.; HIROTSU, C.; ESTEVES, A. M.; BITTENCOURT, L.; ANDERSEN, M. L.; TUFIK, S.. PREVALENCE AND ASSOCIATED FACTORS OF RESTLESS LEGS SYNDROME AND PERIODIC LIMB MOVEMENT IN EPISONO COHORT. Sleep Medicine, v. 40, p. 2-pg., 2017-12-01. (14/15259-2, 15/19136-5)

MORELHAO, PRISCILA K.; ANDERSEN, MONICA L.; TUFIK, SERGIO; PINTO, RAFAEL Z.. Letter to the Editor About the Article "Aquatic Exercises in the Treatment of Low Back Pain: A Systematic Review of the Literature and Meta-Analysis of Eight Studies". AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, v. 97, n. 12, p. 2-pg., 2018-12-01. (15/19136-5)

CARISSIMI, ALICIA; MARTINEZ, DENIS; KIM, LENISE J.; FIORI, CINTIA Z.; VIEIRA, LUCIANA R.; ROSA, DARLAN P.; PIRES, GABRIEL N.. Intermittent hypoxia, brain glyoxalase-1 and glutathione reductase-1, and anxiety-like behavior in mice. Revista Brasileira de Psiquiatria, v. 40, n. 4, p. 376-381, OCT-DEC 2018. (15/19136-5)

MORELHAO, PRISCILA K.; KIM, LENISE J.; PINTO, RAFAEL Z.; TUFIK, SERGIO; ANDERSEN, MONICA L.. Should Physical Therapists Assess Sleep Quality in Patients Seeking Care for Low Back Pain?. PHYSICAL THERAPY, v. 99, n. 8, p. 3-pg., 2019-08-01. (15/19136-5)

HUEBRA, LUCIO; KIM, LENISE JIHE; CARLOS, KARLA; BALSALOBRE, RAFAEL DE ANDRADE; COIN DE CARVALHO, LUCIANE BIZAI; FERNADES DO PRADO, LUCILA BIZARI; DO PRADO, GILMAR FERNANDES; COELHO, FERNANDO MORGADINHO. Granulomatosis With Polyangiitis and Continuous Positive Airway Pressure-The Challenge of Interface Between Nose and Mask. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, v. 24, n. 2, p. 102-103, MAR 2018. (15/19136-5)

SOTERIO-PIRES, J. H.; HIROTSU, C.; KIM, L. J.; BITTENCOURT, L.; TUFIK, S.; ANDERSEN, M. L.. The interaction between erectile dysfunction complaints and depression in men: a cross-sectional study about sleep, hormones and cl uality of life. INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH, v. 29, n. 2, p. 70-75, MAR-APR 2017. (15/02036-8, 15/19136-5)

NOZOE, KAREN TIEME; KIM, LENISE JIHE; POLESEL, DANIEL NINELLO; HIROTSU, CAMILA; DE SOUZA, ALTAY LINO; HACHUL, HELENA; TUFIK, SERGIO BRASIL; TUFIK, SERGIO; ANDERSEN, MONICA LEVY; MOREIRA, GUSTAVO ANTONIO. Sleep pattern and spectral analysis of caregiver-mothers of sons with Duchenne muscular dystrophy, and an examination of differences between carriers and non-carriers. Sleep Medicine, v. 32, p. 114-121, APR 2017. (15/19136-5, 14/08067-0)

MAIA PALHANO, ANA CLARA; KIM, LENISE JIHE; MOREIRA, GUSTAVO A.; SANTOS COELHO, FERNANDO MORGADINHO; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. Narcolepsy, Precocious Puberty and Obesity in the Pediatric Population: a Literature Review. PEDIATRIC ENDOCRINOLOGY REVIEWS PER, v. 16, n. 2, p. 266-274, DEC 2018. (15/19136-5)

KIM, LENISE JIHE; TUFIK, SERGIO; ANDERSEN, MONICA LEVY. Sleep awareness and education among clinical practitioners. CLINICAL MEDICINE, v. 17, n. 4, p. 380, AUG 2017. (15/19136-5)

KIM, L. J.; TUFIK, S.; ANDERSEN, M. L.. EARLY CHILDHOOD SLEEP EDUCATION AS A HEALTH PROMOTION APPROACH: AN EXPERIENCE FROM PILOT PROJECT "THE ART OF DREAMING". Sleep Medicine, v. 40, p. 1-pg., 2017-12-01. (15/19136-5)

CARISSIMI, ALICIA; MARTINEZ, DENIS; KIM, LENISE J.; FIORI, CINTIA Z.; VIEIRA, LUCIANA R.; ROSA, DARLAN P.; PIRES, GABRIEL N.. Intermittent hypoxia, brain glyoxalase-1 and glutathione reductase-1, and anxiety-like behavior in mice. Revista Brasileira de Psiquiatria, v. 40, n. 4, p. 6-pg., 2018-10-01. (15/19136-5)

HIROTSU, C.; KIM, LJ; ESTEVES, A. M.; BITTENCOURT, L.; ANDERSEN, M. L.; TUFIK, S.. EPIDEMIOLOGY OF RESTLESS LEGS SYNDROME AND PERIODIC LIMB MOVEMENT IN THE EPISONO COHORT. Sleep, v. 40, p. 1-pg., 2017-04-01. (14/15259-2, 15/19136-5)