DEVELOPMENT OF POLYMERIC PARTICLES AS CARRIER SYSTEMS FOR BIOACTIVE PRODUCTS

• Grant number: 15/15068-5
• Support type: Scholarships in Brazil - Master
• Effective date (Start): March 01, 2016
• Effective date (End): June 30, 2018
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Priscila Gava Mazzola
• Grantee: Janaína Artem Ataide
• Home Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 17/05275-9 - Bromelain encapsulation: stability, release profile, and cytotoxicity, BE.EP.MS

Abstract

Bromelain is a protease obtained from various species of Bromeliaceae family, which is present on the stem and fruit. It is used in food and pharmaceutical industries based on its proteolytic activity. Bromelain is known for its clinical and therapeutic applications, particularly for the modulation of tumor growth, selective debridement of burns and improved antibiotic and anti-inflammatory action, and antithrombotic and fibrinolytic activities. The polymeric nanoparticles have been intensively researched as promising drug delivery systems. These systems are able to provide greater stability, efficacy and safety for the encapsulated active and have attracted the interest of the pharmaceutical industry. In this scenario, chitosan is emerging as a promising polymer, mainly due to its biocompatible, biodegradable and mucus adherence characteristics. This project aims to develop chitosan-bromelain nanoparticles, which can be highly promising from scientific and technological points of view. In addition, the project also aims the pharmacological activity and toxicity evaluation in vitro of the developed nanoparticles.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ATAIDE, JANAINA ARTEM; CEFALI, LETICIA CARAMORI; CROISFELT, FERNANDA MACHADO; MARTINS SHIMOJO, ANDREA ARRUDA; OLIVEIRA-NASCIMENTO, LAURA; MAZZOLA, PRISCILA GAVA. Natural actives for wound healing: A review. Phytotherapy Research, v. 32, n. 9, p. 1664-1674, SEP 2018. Web of Science Citations: 4.