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Ghrelin participation in controlling blood pressure and heart rate during endotoxemic shock in animals subjected to neonatal exposure to lipopolysaccharide

Grant number: 15/19723-8
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2016
Effective date (End): December 31, 2016
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal researcher:Evelin Capellari Cárnio
Grantee:Fabio Cardoso
Home Institution: Escola de Enfermagem de Ribeirão Preto (EERP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Sepsis is defined as systemic inflammatory response syndrome (SIRS) caused by infection. The etiological focus usually occurs by Gram-negative bacteria, which have lipopolysaccharide (LPS) in its outer shell. LPS activates the host inflammatory cascade releasing the pro-inflammatory cytokines. Studies have shown that neonatal immune environment can have an effect on the neuroimmune response in the adult. Contact neonatal rat LPS can alter neuroendocrine, neurochemical and febrile responses. In adulthood, these animals will have its amended neuroimunológica capacity and when subjected to LPS, your body will react differently to the stimulus. High levels of TNF-± and IL-1² produced by cells of the immune system are related to the severity of septic shock, such as hypotension, cardiodepressores effects and death. The hypotensive and cardiodepressores effects induced by LPS during endotoxêmico shock are attenuated when the animals are pre-exposed to endotoxin in the neonatal period. It is assumed that contact the neonate LPS causes a decrease in the synthesis of pro inflammatory cytokines due to increased glucocorticoids in the plasma, thereby reducing nitric oxide (NO) which is an important agent in the hypotensive of sepsis. Ghrelin is a hormone "hunger" and acts in the regulation of inflammation, reducing the pro-inflammatory state and enhancing the anti-inflammatory state. With ghrelin serum levels of cytokines induced by LPS could be mitigated. Therefore, our objective is to evaluate the effect of systemic administration of ghrelin antagonist on blood pressure and heart rate during endotoxêmico shock induced by LPS in mice that already had contact with the infectious agent in the newborn period.

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