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Effect of sympathetic inhibition and vagal activation on inflammatory mediators in endotoxemic rats

Grant number: 20/08312-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2020
Effective date (End): August 31, 2021
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal researcher:Helio Cesar Salgado
Grantee:Luiz Gustavo Silva Cesarino
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:13/20549-7 - New insights in cardiovascular regulation under physiological and pathophysiological condition, AP.TEM

Abstract

Besides presenting baroreflex dysfunction, hypertensive patients also exhibit an increased inflammatory profile, suggesting a possible correlation between the baroreflex function integrity and the immune system. Although studies of our laboratory have shown the anti-inflammatory effects of baroreflex, no previous study explored the physiological reflex activation of the baroreflex, instead of its direct activation, in experimental models of systemic inflammation. The abdominal aortic coarctation (AAC) is a useful approach, able to promote the physiological reflex activation of the baroreflex and may contribute to better understand the anti-inflammatory potential of the baroreflex. Thus, the aim of the present study is to evaluate the effects of physiological activation of baroreflex, through AAC in unanesthetized rats, in the systemic inflammatory response induced by lipopolysaccharide (LPS) administration; as well as to explore the possible changes in arterial pressure and heart rate due to the systemic inflammation process and/or AAC. For this, under anesthesia, a cuff will be implanted around the abdominal aorta of Sprague-Dawley male rats, and the carotid artery and femoral vein will be cannulated. On the next day, with unanesthetized subjects, the hemodynamic parameters will be recorded (arterial pressure and heart rate), AAC will be performed during 120 s, and next, the LPS (1.5 mg/kg, i.v.), or saline, will be injected. The hemodynamic parameters will be recorded during 90 min after the injection of LPS, or saline. Blood sample and spleen will be collected for plasmatic and splenic cytokines analysis.

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