The effects of body mass reduction on the blood levels of Th17 family citokynes in subjects submitted to Roux-en-Y gastric bypass

• Grant number: 15/12020-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2015
• End date: October 31, 2016
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Licio Augusto Velloso
• Grantee: Aline Inácio Pereira
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center, AP.CEPID

Abstract

The prevalence of obesity and overweight has been increasing in the last years, and it is multifactorial problem involving behavior as well as cultural, genetic and psychological aspects. However, some studies indicate that a sedentary lifestyle and the consumption of hypercaloric diet are the main responsible for this phenomenon. Because of its high prevalence and its clinical association with diabetes mellitus, atherosclerosis, hypertension and some type of cancers, obesity has become one of the most important public health diseases in the world, and for this reason intense efforts in research are been conducted for more effective prophylactic and therapeutic methods. Over the past twenty years, some studies have shown that frequently during the development of obesity, there is a global subclinical inflammatory response, which results in the inhibition of the insulin signaling pathways. This inhibitory mechanism is responsible for insulin resistance and eventually glucose intolerance in the type-2 diabetes. The inflammatory activity in obesity is caused predominantly by the activation of the innate response. However, studies conducted in our laboratory (PhD Project 2010 / 52378-9) indicate that the cytokine IL17, a central component of the adaptive response Th17 pathway produced by the gut, is modulated by the dietary fatty acids. The aims of this project are to evaluate the serum levels of Th17 pathway components, interleukin 17, 22 and 23, in obese patients before and eight months after Roux-en-Y gastric bypass. This project will allow the understanding of mechanisms involved in the characteristic inflammatory process of obesity development so that it can be better clarified, which in the future may help to establish new strategies for prevention, control and treatment of the obesity.