| Grant number: | 15/25381-2 |
| Support type: | Scholarships in Brazil - Post-Doctorate |
| Effective date (Start): | March 01, 2016 |
| Effective date (End): | February 28, 2018 |
| Field of knowledge: | Biological Sciences - Microbiology - Biology and Physiology of Microorganisms |
| Principal Investigator: | Shaker Chuck Farah |
| Grantee: | Ethel Bayer Santos |
| Home Institution: | Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Associated research grant: | 11/07777-5 - Cyclic di-GMP signaling and the Type IV macromolecule secretion system in Xanthomonas citri, AP.TEM |
Abstract Bacterial secretion systems are versatile structures that can secrete proteins and DNA into the extracellular medium or into target cells. Type IV secretion systems (T4SS) are protein complexes formed by 12 proteins (VirB1-VirB11 and VirD4) that play a fundamental role in the virulence of several bacterial species. In the last ten years, our laboratory has been studying interactions involving subunits of the T4SS of Xanthomonas citri, the causative agent of canker citrus, and identified 12 protein substrates secreted by this system. Recently, we demonstrated that T4SS of X. citri is capable of killing other bacterial species, thus working in an analogous manner to the type VI secretion system (T6SS). Once the T4SS of X. citri operates analogously to the T6SS of a variety of bacterial species, such as Vibrio cholerae and Pseudomonas aeruginosa, which are able to inject toxins in both prokaryotic and eukaryotic cells; this project aims to study the role of X. citri T4SS in interactions with a phagocytic eukaryotic cell, such as the social amoeba Dictyostelium discoideum. In addition, this project aims to study the T4SS of the opportunistic pathogen Stenotrophomonas maltophilia to determine whether this secretion system could play a similar role in other species phylogenetically related to Xanthomonas spp. The characterization of the S. maltophilia T4SS and its secreted toxins will be of great value to increase our knowledge about the biology and virulence mechanisms of this emerging pathogen. The knowledge generated at the end of this project will increase our understanding of the ecology of free-living bacteria and the mechanisms by which they survive their environmental predators. | |
| Matéria(s) publicada(s) na Agência FAPESP sobre a bolsa: | |
| Researchers show how opportunistic bacterium defeats competitors | |
| Articles published in other media outlets: (19 total) | |
| Científicos develan cómo una bacteria oportunista derrota a sus competidoras | |
| Pesquisadores desvendam como bactéria oportunista derrota competidoras | |
| Pesquisadores desvendam como bactéria oportunista derrota competidoras | |
| Pesquisadores desvendam como bactéria oportunista derrota competidoras | |
| Pesquisadores desvendam como bactéria oportunista derrota competidoras | |
| Pesquisadores desvendam como bactéria oportunista derrota competidoras | |
| Pesquisadores desvendam como bactéria oportunista derrota competidores | |
| Pesquisadores desvendam como bactéria oportunista derrota competidoras | |
| Pesquisadores desvendam como bactéria oportunista derrota competidoras | |
| Pesquisadores desvendam como bactéria oportunista derrota competidoras | |
| Bactéria contra bactéria pode render novos antibióticos | |
| Pesquisadores desvendam como bactéria oportunista derrota competidoras | |
| Investigadores revelan como bacterias oportunistas derrotan a competidoras | |
| Descoberto como bactéria oportunista de hospitais elimina oponentes | |
| Researchers show how opportunistic bacterium defeats competitors | |
| Researchers show how opportunistic bacterium defeats competitors | |
| Researchers show how opportunistic bacterium defeats competitors | |
| Researchers show how opportunistic bacterium defeats competitors | |
| Researchers show how opportunistic bacterium defeats competitors | |
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