| Grant number: | 15/21460-5 |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| Start date: | March 01, 2016 |
| End date: | November 25, 2019 |
| Field of knowledge: | Biological Sciences - Physiology - Compared Physiology |
| Principal Investigator: | Márcio Reis Custódio |
| Grantee: | Vinicius Queiroz Araújo |
| Host Institution: | Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Associated scholarship(s): | 18/14497-8 - Physiological function and origin of the spherulocytes in the sea urchin Paracentrotus lividus (Echinodermata: Echinoidea), BE.EP.DR |
Abstract The blood is a complex tissue possessing very important functions in animal physiology. In the vertebrates, mainly in mammals, the knowledge is high and much is know about the cells forming this tissue. To the invertebrates, this scenario is much different. In these organisms, the celomic fluid is the correspondent to the vertebrate blood, and the cells in this tissue (the coelomocytes) have related roles. Nevertheless, the specific functions of the coelomic cells are poor know. In echinoderms only a cell type, the phagocyte, has been deeply studied. Other coelomic cells, such as the spherulocytes, has been neglected and very few is know about the real amount of subpopulations, the nature of the cytoplasmic inclusion as well as the origin and physiological function of these cells. Thus, in the present project, the goal is to investigate the physiological function of the echinoderms' spherulocytes using sea urchins (Echinoidea) as model organisms. To assess these functions it will be used urchins and sand-dollars, whose spherulocytes subpopulations will first be isolated, characterized and subsequently the cytoplasmic contents will be identified. From these data, it will be performed the experiments regarding the potential physiological roles of these cells. Finally, we will investigate the possible source of origin to these coelomic cells. To achieve these goals, it will be performed some procedures such as: centrifugation in density gradients, flow cytometry, histology, electron microscopy (transmission and scanning), mass spectrometry and larvae farming. | |
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