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Effects of mesenchymal stem cells (MSCs) on endothelial function: in vitro and in vivo studies.

Grant number: 16/01746-4
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): May 01, 2016
Effective date (End): April 30, 2017
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal researcher:Helena Coutinho Franco de Oliveira
Grantee:Amarylis Claudine Bonito Azeredo Wanschel
Supervisor abroad: Joshua Hare
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Research place: University of Miami, United States  
Associated to the scholarship:13/09347-3 - Effect of the expression of the cholesteril ester transfer protein (CETP) on the endothelial function: studies in transgenic mice and in vitro, BP.PD


Despite remarkable progress, cardiovascular disease (CVD) remains a major cause of morbidity, mortality, and impaired quality of life worldwide. Endothelial dysfunction is a central feature of the pathophysiology of numerous CVDs and manifests in patients with CV risk factors such as atherosclerosis, hypertension, and diabetes mellitus. For this reason, the endothelium may represent a powerful target in the development of new treatments for CV disease. Mesenchymal stem cells (MSCs) have been utilized for therapeutic applications. MSCs are multipotent cells capable of differentiating into different cell types and exert antiproliferative, immunomodulatory, and anti-inflammatory effects. One cell type with which MSCs might interact during cardiovascular healing is the endothelial cell (EC). Here, we hypothesize that the interaction between transplanted MSCs and ECs promotes endothelial healing, modulating eNOS activity and nitric oxide production and/or restore vascular permeability and endothelial inflammation.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
WANSCHEL, AMARYLIS C. B. A.; GUIZONI, DANIELE M.; LORZA-GIL, ESTELA; SALERNO, ALESSANDRO G.; PAIVA, ADRIENE A.; DORIGHELLO, GABRIEL G.; DAVEL, ANA PAULA; BALKAN, WAYNE; HARE, JOSHUA M.; OLIVEIRA, HELENA C. F. The Presence of Cholesteryl Ester Transfer Protein (CETP) in Endothelial Cells Generates Vascular Oxidative Stress and Endothelial Dysfunction. BIOMOLECULES, v. 11, n. 1 JAN 2021. Web of Science Citations: 0.

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